S
Sacha M.L. Khong
Researcher at Stanford University
Publications - 13
Citations - 679
Sacha M.L. Khong is an academic researcher from Stanford University. The author has contributed to research in topics: Mesenchymal stem cell & Arginase. The author has an hindex of 11, co-authored 13 publications receiving 522 citations. Previous affiliations of Sacha M.L. Khong include Monash University, Clayton campus & Baker IDI Heart and Diabetes Institute.
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Journal ArticleDOI
Injectable and Tunable Gelatin Hydrogels Enhance Stem Cell Retention and Improve Cutaneous Wound Healing
Yixiao Dong,Yixiao Dong,Sigen A,Melanie Rodrigues,Xiaolin Li,Sun H. Kwon,Nina Kosaric,Sacha M.L. Khong,Yongsheng Gao,Wenxin Wang,Geoffrey C. Gurtner +10 more
TL;DR: The data suggest that injectable PEG–gelatin hydrogel can be used for regulating stem cell behaviors in 3D culture, delivering cells for wound healing and other tissue regeneration applications.
Journal ArticleDOI
Aging disrupts cell subpopulation dynamics and diminishes the function of mesenchymal stem cells
Dominik Duscher,Robert C. Rennert,Michael Januszyk,Ersilia Anghel,Zeshaan N. Maan,Alexander J. Whittam,Marcelina G. Perez,Revanth Kosaraju,Michael S. Hu,Graham G. Walmsley,David Atashroo,Sacha M.L. Khong,Atul J. Butte,Geoffrey C. Gurtner +13 more
TL;DR: It is suggested that age-related changes in MSC population dynamics result in impaired therapeutic potential of aged progenitor cells and this finding has critical implications for therapeutic cell source decisions and indicate the necessity of strategies to improve functionality of aged MSCs.
Journal ArticleDOI
Alveolar macrophages are critical for the inhibition of allergic asthma by mesenchymal stromal cells.
Louisa Mathias,Sacha M.L. Khong,Lisa Garifalia Spyroglou,Natalie Lisa Payne,Christopher Siatskas,Alison N. Thorburn,Richard L. Boyd,Tracy Heng +7 more
TL;DR: It is demonstrated that human MSCs exert cross-species immunosuppressive activity, which is mediated by alveolar macrophages in allergic asthma, and selective depletion of this macrophage compartment reversed the therapeutic benefit of MSC treatment on airway hyperresponsiveness.
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Comparison of the Hydroxylase Inhibitor Dimethyloxalylglycine and the Iron Chelator Deferoxamine in Diabetic and Aged Wound Healing.
Dominik Duscher,Michael Januszyk,Zeshaan N. Maan,Alexander J. Whittam,Michael S. Hu,Graham G. Walmsley,Yixiao Dong,Sacha M.L. Khong,Michael T. Longaker,Geoffrey C. Gurtner +9 more
TL;DR: This first direct comparison of deferoxamine and dimethyloxalylglycine in the treatment of impaired wound healing suggests significant therapeutic potential for topical deferredoxamine treatment in ischemic and diabetic disease.
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Single‐Cell Transcriptomics of Human Mesenchymal Stem Cells Reveal Age‐Related Cellular Subpopulation Depletion and Impaired Regenerative Function
Sacha M.L. Khong,Ming Lee,Ming Lee,Nina Kosaric,Danika Khong,Yixiao Dong,Ursula Hopfner,Matthias M. Aitzetmüller,Dominik Duscher,Dominik Duscher,Richard Schäfer,Geoffrey C. Gurtner +11 more
TL;DR: It is found that BM‐MSCs from young donors healed wounds in a xenograft model faster compared with their aged counterparts (p < .001), and single‐cell transcriptomic analysis was used to provide potential molecular insights into these observations.