N
Niraj Kumar Jha
Researcher at Sharda University
Publications - 120
Citations - 2224
Niraj Kumar Jha is an academic researcher from Sharda University. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 15, co-authored 117 publications receiving 744 citations. Previous affiliations of Niraj Kumar Jha include Noida Institute of Engineering and Technology & Delhi Technological University.
Papers
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Journal ArticleDOI
Oxidative Stress in Cancer Cell Metabolism.
Saniya Arfin,Niraj Kumar Jha,Saurabh Kumar Jha,Kavindra Kumar Kesari,Janne Ruokolainen,Shubhadeep Roychoudhury,Brijesh Rathi,Dhruv Kumar +7 more
TL;DR: In this paper, the authors provide an overview of the generation and sources of reactive oxygen species within tumor cells, ROS-associated signaling pathways, their regulation by antioxidant defense systems, as well as the effect of elevated ROS production in tumor progression.
Journal Article
p38 MAPK and PI3K/AKT Signalling Cascades in Parkinson's Disease
TL;DR: Many established mechanisms involving the p38 MAPK and PI3K/AKT pathways which can offer therapeutic windows for the rectification of aberrant DA neuronal dynamics in PD brains are outlined.
Journal ArticleDOI
Nuclear factor-kappa β as a therapeutic target for Alzheimer's disease.
TL;DR: Since any impairment in the pathways associated with NF‐κβ signaling causes altered neuronal dynamics, neurotherapeutics using compounds including, antioxidants, bioflavonoids, and non‐steroidal anti‐inflammatory drugs against such abnormalities offer possibilities to rectify aberrant excitatory neuronal activity in AD.
Journal ArticleDOI
Linking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration.
TL;DR: The pertinent role of MetS induced mitochondrial dysfunction in neurons and their consequences in NDDs is elucidated and therapeutic potential of well-known biomolecules and chaperones to target altered mitochondria has been comprehensively documented.
Book ChapterDOI
Ion Channels in Neurological Disorders
TL;DR: The potential role of the ion channels in membrane physiology and brain homeostasis is reviewed, where ion channels and their associated factors have been characterized with their functional consequences in neurological diseases.