Nobuhiro Kimura

TL;DR: It is demonstrated that genomic rearrangements are responsible for p53 gene Jnactivation in these cell lines and that they occur in vivo during the natural progression of Friend virus-induced erythroleukaemia.

TL;DR: To compare and contrast the human T cell antigen receptor (TcR) α and β chain messages found in human thymocytes to those previously isolated from human peripheral blood T lymphocytes and other nonthymic sources, the nucleotide sequences were determined and a revised estimate of human TcR Vα, Jα and Vβ repertoires is calculated.

TL;DR: The nucleotide sequences of 22 human T cell antigen receptor (TcR) beta chain variable region genes isolated from various T lymphocytes have been analyzed and are consistent with a total V beta gene segment repertoire with a most probable value of 38 members and an upper bound of 104 members at the 95% confidence level.

TL;DR: Identical nucleotide sequences in independent isolates of V alpha and J alpha gene segments indicate that hypermutation may not be a common mechanism for the expansion of diversity in these genes, and suggest that the major source of diversity within the alpha chain repertoire is a result of recombinational joinings between germline VAlpha and JAlpha sequences.

TL;DR: Evidence of greater germ‐line multiplicity and more extensive use of junctional flexibility, N‐region diversity and perhaps Dγ gene segment incorporation was observed, and the role of the human T cell γ gene becomes even more uncertain than before.