A
Alan Bernstein
Researcher at Global HIV Vaccine Enterprise
Publications - 199
Citations - 22433
Alan Bernstein is an academic researcher from Global HIV Vaccine Enterprise. The author has contributed to research in topics: Gene & Receptor tyrosine kinase. The author has an hindex of 72, co-authored 199 publications receiving 21977 citations. Previous affiliations of Alan Bernstein include Memorial Sloan Kettering Cancer Center & Mount Sinai Hospital, Toronto.
Papers
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Journal ArticleDOI
The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus.
TL;DR: Observations provide the first example of a germ-line mutation in a mammalian proto-oncogene and implicate the c-kit gene as a candidate for the W locus and provide a molecular entry into this important region of the mouse genome.
Journal ArticleDOI
W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity
Jan D. Huizinga,Lars Thuneberg,Michael Klüppel,Michael Klüppel,John Malysz,H. B. Mikkelsen,Alan Bernstein,Alan Bernstein +7 more
TL;DR: It is shown that the interstitial cells of Cajal express the Kit receptor tyrosine kinase, and mice with mutations in the dominant white spotting locus, which have cellular defects in haematopoiesis, melanogenesis and gametogenesis, also lack the network of intestitial cells ofCajal associated with Auerbach's nerve plexus and intestinal pacemaker activity.
Book
RNA tumor viruses
Robin A. Weiss,Alan Bernstein +1 more
TL;DR: This book contains 12 selections of retroviral diseases and some of the titles are: Genome Structure;Genetics of Retroviruses;Functions and Origins of Retoviral Transforming Genes;Human T-cell RetrovIRuses;Replications of Retrospective Viruses; and Endogenous Viruses.
Journal ArticleDOI
A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis.
Fouad Shalaby,Jacqueline Ho,William L. Stanford,Klaus D. Fischer,Andre C. Schuh,Lois Schwartz,Alan Bernstein,Janet Rossant,Janet Rossant +8 more
TL;DR: It is demonstrated that cells lacking Flk1 are unable to reach the correct location to form blood islands, suggesting that FlK1 is involved in the movement of cells from the posterior primitive streak to the yolk sac and, possibly, to the intraembryonic sites of early hematopoiesis.
Journal ArticleDOI
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells.
Seiji Hitoshi,Tania O. Alexson,Vincent Tropepe,Dorit B. Donoviel,Andrew J. Elia,Jeffrey S. Nye,Ronald A. Conlon,Tak W. Mak,Alan Bernstein,Derek van der Kooy +9 more
TL;DR: Both neuronal and glial differentiation in vitro were enhanced by attenuation of Notch signaling and suppressed by expressing an active form of NotCh1, consistent with a role for NotCh signaling in the maintenance of the neural stem cell, and inconsistent with a roles in a neuronal/glial fate switch.