Y
Yasunobu Yoshikai
Researcher at Ontario Institute for Cancer Research
Publications - 16
Citations - 3601
Yasunobu Yoshikai is an academic researcher from Ontario Institute for Cancer Research. The author has contributed to research in topics: T-cell receptor & Gene. The author has an hindex of 13, co-authored 16 publications receiving 3570 citations.
Papers
More filters
Journal ArticleDOI
A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains
Yusuke Yanagi,Yasunobu Yoshikai,Kathleen Leggett,Stephen P. Clark,Ingrid Aleksander,Tak W. Mak +5 more
TL;DR: A cloned and sequenced a human mRNA specific for mammalian T-lymphoid cells found to be expressed in human and murine T lymphoblasts, thymocytes and phytohaemagglutinin-stimulated T lymphocytes suggests that the cDNA clone may correspond to a message that specifies part of the human T-cell receptor.
Journal ArticleDOI
Mouse T cell antigen receptor: Structure and organization of constant and joining gene segments encoding the β polypeptide
Marie Malissen,Karyl Minard,Shelley Mjolsness,Mitchell Kronenberg,Joan Goverman,Tim Hunkapiller,Michael B. Prystowsky,Yasunobu Yoshikai,Frank W. Fitch,Tak W. Mak,Leroy Hood +10 more
TL;DR: The germ-line joining (J) gene segments and constant (C) genes encoding the beta chain of the mouse T cell antigen receptor have been isolated on a single cosmid clone and both C beta genes appear functional.
Journal ArticleDOI
Sequence and expression of transcripts of the human T-cell receptor β-chain genes
Yasunobu Yoshikai,Demetri Anatoniou,Stephen P. Clark,Yusuke Yanagi,Robert Sangster,Peter Van den Elsen,Cox Terhorst,Tak W. Mak +7 more
TL;DR: T lymphocytes can produce mRNAs from the first or second constant region of the T-cell antigen receptor β-chain, which contains V, J and one of the two C region sequences, but does not always contain D sequences.
Journal ArticleDOI
Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer
Pamela S. Ohashi,Tak W. Mak,Peter J. van den Elsen,Yusuke Yanagi,Yasunobu Yoshikai,Andrew F. Calman,Cox Terhorst,John D. Stobo,Arthur Weiss +8 more
TL;DR: Exposure to the transfected β-chain led to a normal level of α-chain transcript and a structurally and functionally active T3 T-cell antigen receptor complex on the cell surface.
Journal ArticleDOI
The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene
Gerald Siu,Stephen P. Clark,Yasunobu Yoshikai,Marie Malissen,Yusuke Yanagi,Erich Strauss,Tak W. Mak,Leroy Hood +7 more
TL;DR: A cDNA clone YT35, synthesized from poly(A)+ RNA of the human T cell tumor Molt 3, exhibits homology to the variable (V), joining (J), and constant (C) regions of immunoglobulin genes.