N
Nobuko Tsuchida-Straeten
Publications - 2
Citations - 117
Nobuko Tsuchida-Straeten is an academic researcher. The author has contributed to research in topics: Gene & Gastrulation. The author has an hindex of 1, co-authored 1 publications receiving 102 citations.
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Gli2 is a novel regulator of sox2 expression in telencephalic neuroepithelial cells
Hiromi Takanaga,Nobuko Tsuchida-Straeten,Kenji Nishide,Akira Watanabe,Hiroyuki Aburatani,Toru Kondo +5 more
TL;DR: It is demonstrated that coexpression of Gli2ΔC and Sox2 can rescue the expression of Hes5 and prevent premature neuronal differentiation in NE cells but cannot rescue its proliferation, revealing a novel transcriptional cascade, involving Gli 2 → Sox2 → Hes5, which maintains the undifferentiated state of telencephalic NE cells.
Journal ArticleDOI
An ex vivo system to study cellular dynamics underlying mouse peri-implantation development
Takafumi Ichikawa,Hui Ting Zhang,Laura Panavaite,Anna Erzberger,Dimitri Fabrèges,Rene Snajder,Adrian Wolny,Ekaterina Korotkevich,Nobuko Tsuchida-Straeten,Lars Hufnagel,Anna Kreshuk,Takashi Hiiragi +11 more
TL;DR: This article developed an ex vivo Matrigel-collagen-based culture to recapitulate mouse development from E4.5 to E6.0, which not only recapitulates embryonic growth, axis initiation and overall 3D architecture in 49% of the cases, but its compatibility with light-sheet microscopy also enables the study of cellular dynamics through automatic cell segmentation.