N
Nobuo Shimma
Researcher at Hoffmann-La Roche
Publications - 92
Citations - 3268
Nobuo Shimma is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Alkyl & Capecitabine. The author has an hindex of 24, co-authored 92 publications receiving 3160 citations. Previous affiliations of Nobuo Shimma include Chugai Pharmaceutical Co..
Papers
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Journal ArticleDOI
Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue
Masanori Miwa,Masako Ura,Miwa Nishida,Noriaki Sawada,Tohru Ishikawa,Kazushige Mori,Nobuo Shimma,I. Umeda,Hideo Ishitsuka +8 more
TL;DR: Capecitabine, which is finally converted to 5-FU by dThdPase in tumours, should be much safer and more effective than5-FU, and this was indeed the case in the HCT116 human colon cancer and the MX-1 breast cancer xenograft models.
Journal ArticleDOI
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, Capecitabine
Nobuo Shimma,Isao Umeda,Motohiro Arasaki,Chikako Murasaki,Kazunao Masubuchi,Yasunori Kohchi,Masanori Miwa,Masako Ura,Noriaki Sawada,Hitoshi Tahara,Isamu Kuruma,Ikuo Horii,Hideo Ishitsuka +12 more
TL;DR: In tests with various human cancer xenograft models, capecitabine was more efficacious at wider dose ranges than either 5-FU or 5'-DFUR and was significantly less toxic to the intestinal tract than the others in monkeys.
Patent
Nucleoside derivatives for the treatment of hepatitis c
Rene Devos,Brian William Dymock,Christopher John Hobbs,Wen-Rong Jiang,Martin Joseph Armstrong,John Herbert Merrett,Isabel Najera,Nobuo Shimma,Takuo Tsukuda +8 more
TL;DR: The use of compounds of formula (I) is defined in this paper, where the use of I is defined as the mixture of two or more carbon atoms, each of which is substituted with four different substituents.
Patent
4'-substituted nucleoside derivatives as inhibitors of hcv rna replication
Devos Rene Robert,Hobbs Christopher John,Jiang Wen-Rong,Joseph Armstrong Martin,Merrett John Herbert,Najera Isabel,Nobuo Shimma,Takuo Tsukuda +7 more
TL;DR: In this article, the use of nucleoside derivatives of formula I for the treatment of diseases mediated by the hepatitis C Virus (HCV) for the preparation of a medicament for such treatment and to pharmaceutical compositions containing such compounds.
Patent
Anti-HCV nucleoside derivatives
Rene Devos,Brian Dymock,Hobbs Christopher John,Wen-Rong Jiang,Joseph A. Martin,John Herbert Merrett,Isabel Najera,Nobuo Shimma,Takuo Tsukuda +8 more
TL;DR: In this paper, the use of known 2′-deoxy-2′-fluoro nucleoside derivatives as inhibitors of hepatitis C virus (HCV) RNA replication and pharmaceutical compositions of such compounds are described.