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Nobuyuki Yamamoto
Researcher at Kindai University
Publications - 17
Citations - 914
Nobuyuki Yamamoto is an academic researcher from Kindai University. The author has contributed to research in topics: Lung cancer & Epidermal growth factor receptor. The author has an hindex of 14, co-authored 17 publications receiving 850 citations.
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Journal ArticleDOI
Phase I pharmacokinetic trial of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (‘Iressa’, ZD1839) in Japanese patients with solid malignant tumors
Kazuhiko Nakagawa,Tomohide Tamura,S. Negoro,S. Kudoh,Nobuyuki Yamamoto,Koji Takeda,H. Swaisland,I. Nakatani,M. Hirose,R.-P. Dong,Masahiro Fukuoka +10 more
TL;DR: Gefitinib showed a favorable tolerability profile in Japanese patients and the safety profile, pharmacokinetic parameters and antitumor activity observed in the study are comparable to those observed in patients from the USA and Europe.
Journal ArticleDOI
Phase III Study Comparing Second- and Third-Generation Regimens With Concurrent Thoracic Radiotherapy in Patients With Unresectable Stage III Non–Small-Cell Lung Cancer: West Japan Thoracic Oncology Group WJTOG0105
Nobuyuki Yamamoto,Kazuhiko Nakagawa,Yasumasa Nishimura,Kayoko Tsujino,Miyako Satouchi,Shinzoh Kudo,Toyoaki Hida,Masaaki Kawahara,Koji Takeda,Nobuyuki Katakami,Toshiyuki Sawa,Soichiro Yokota,Takashi Seto,Fumio Imamura,Hideo Saka,Yasuo Iwamoto,Hiroshi Semba,Yasutaka Chiba,Hisao Uejima,Masahiro Fukuoka +19 more
TL;DR: Arm C was equally efficacious and exhibited a more favorable toxicity profile among three arms and should be considered a standard regimen in the management of locally advanced unresectable NSCLC.
Journal Article
LAT1 expression is closely associated with hypoxic markers and mTOR in resected non-small cell lung cancer.
Kyoichi Kaira,Noboru Oriuchi,Toshiaki Takahashi,Kazuo Nakagawa,Yasuhisa Ohde,Takehiro Okumura,Haruyasu Murakami,Takehito Shukuya,Hirotsugu Kenmotsu,Tateaki Naito,Yoshikatsu Kanai,Masahiro Endo,Haruhiko Kondo,Takashi Nakajima,Nobuyuki Yamamoto +14 more
TL;DR: LAT1 expression is closely correlated with hypoxic markers and mTOR pathway in patients with resected NSCLC and overexpression of LAT1 was closely associated with poor outcome in patient with AC.
Journal Article
Phase II study of weekly paclitaxel for relapsed and refractory small cell lung cancer.
Nobuyuki Yamamoto,Junji Tsurutani,Naruo Yoshimura,Gyo Asai,Azusa Moriyama,Kazuhiko Nakagawa,Shinzo Kudoh,Minoru Takada,Yoshiaki Minato,Masahiro Fukuoka +9 more
TL;DR: Paclitaxel, administered as a weekly infusion at a dose of 80 mg/m2, was effective in treating relapsed and refractory SCLC.
Journal ArticleDOI
Correlation Between 18F-FDG Uptake on PET and Molecular Biology in Metastatic Pulmonary Tumors
Kyoichi Kaira,Takehiro Okumura,Yasuhisa Ohde,Toshiaki Takahashi,Haruyasu Murakami,Noboru Oriuchi,Masahiro Endo,Haruhiko Kondo,Takashi Nakajima,Nobuyuki Yamamoto +9 more
TL;DR: The amount of 18F-FDG uptake in metastatic pulmonary tumors is determined by the presence of glucose metabolism (Glut1), phosphorylation of glucose (hexokinase I), hypoxia (HIF-1α), and angiogenesis (VEGF and microvessel density).