Noelle Lucke-Wold

TL;DR: A current estimated annual thrombectomy rate of three procedures per 100 000 people indicates significant potential increase in the volume of endovascular procedures and the need to develop systems of care.

TL;DR: Patients with M2 occlusions and higher baseline deficits (NIHSS score ≥9) may benefit from endovascular therapy, thus potentially expanding the category of acute ischemic strokes amenable to intervention.

TL;DR: Assessment of peripheral blood cfDNA levels may be useful for the identification of ischaemic stroke in the acute care setting, and associative evidence that cfDNA is a potential activator of the peripheral innate immune system in response to cerebral ischaemia is provided.

TL;DR: The transcriptional pattern identified in this study shows strong diagnostic potential, and warrants further evaluation to determine its true clinical efficacy.

TL;DR: The role of inflammation in stroke and in particular, the role of inflammatory cell recruitment and macrophage phenotype in the inflammatory process is reviewed and an increasing role of neuro-immune crosstalk is indicated, which has led to increased interest in identification of peripheral biomarkers indicative of neural injury.