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Norbert Bischofberger
Researcher at Genentech
Publications - 27
Citations - 1290
Norbert Bischofberger is an academic researcher from Genentech. The author has contributed to research in topics: Nucleoside & Thymidine. The author has an hindex of 12, co-authored 27 publications receiving 1284 citations.
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Nucleic acid intercalating agents
TL;DR: Pyridinone or pyrimidine nucleoside bases containing fused aromatic polycyclic rings are provided in this paper, which can be used as improved probes, diagnostic reagents, or for cleaving or derivatizing predetermined domains within nucleic acids.
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Synthesis, hybridization properties and antiviral activity of lipid-oligodeoxynucleotide conjugates
TL;DR: The antiviral activity depended on the sequence of the oligodeoxynucleotide, but some compounds having little or no base complementarity to the viral target were also effective and were not toxic to the cells.
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Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site: Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Antiinfluenza Activity.
Choung U. Kim,Willard Lew,Matthew A. Williams,Hua-Kun Liu,Lijun Zhang,S. Swaminathan,Norbert Bischofberger,Min Chen,Dirk B. Mendel,C. Y. Tai,W. G. Laver,Raymond C. Stevens +11 more
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Synthesis and influenza neuraminidase inhibitory activity of aromatic analogues of sialic acid
TL;DR: Aromatic analogues of sialic acid have been synthesized as potential influenza neuraminidase inhibitors but compound 3, possessing the glycerol side chain at the C 5 position, was not a neuraminidsase inhibitor.
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Thermal denaturation profiles and gel mobility shift analysis of oligodeoxynucleotide triplexes
TL;DR: The dependence of the thermal denaturation profiles on pH, salt concentration, GC content, strand orientation, base mismatches, and strand length was investigated.