L
Lijun Zhang
Researcher at Australian National University
Publications - 27
Citations - 2844
Lijun Zhang is an academic researcher from Australian National University. The author has contributed to research in topics: Neuraminidase & Prodrug. The author has an hindex of 18, co-authored 27 publications receiving 2674 citations.
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Journal ArticleDOI
Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity.
C U Kim,W. Lew,M.A. Williams,Hua-Kun Liu,Lijun Zhang,S Swaminathan,N Bischofberger,Min Chen,D. B. Mendel,C. Y. Tai,W. G. Laver,Raymond C. Stevens +11 more
TL;DR: The design, synthesis, and in vitro evaluation of the novel carbocycles as transition-state-based inhibitors of influenza neuraminidase (NA) are described and the presence of a large hydrophobic pocket in the region corresponding to the glycerol subsite of sialic acid is revealed.
Journal ArticleDOI
Structure−Activity Relationship Studies of Novel Carbocyclic Influenza Neuraminidase Inhibitors
Choung U. Kim,W. Lew,M.A. Williams,Huiwei Wu,Lijun Zhang,Xiaowu Chen,Paul A. Escarpe,D. B. Mendel,W. G. Laver,Raymond C. Stevens +9 more
TL;DR: From the extensive structure-activity relationship investigation reported in this article, GS 4071 emerged as one of the most potent influenza neuraminidase inhibitors against both influenza A and B strains.
Journal ArticleDOI
Oral Administration of a Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 Protects Mice and Ferrets against Influenza Infection
Dirk B. Mendel,Chun Y. Tai,Paul A. Escarpe,Weixing Li,Robert W. Sidwell,John H. Huffman,Clive Sweet,Kenneth J. Jakeman,James R. Merson,Steven A. Lacy,Willard Lew,Matthew A. Williams,Lijun Zhang,Ming S. Chen,Norbert Bischofberger,Choung U. Kim +15 more
TL;DR: The results indicate that GS 4104 is a novel, orally active antiviral agent with the potential to be used for the prophylaxis and treatment of influenza A and B virus infections.
Journal ArticleDOI
Identification of GS 4104 as an Orally Bioavailable Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071
Weixing Li,Paul A. Escarpe,Eugene J. Eisenberg,Kenneth C. Cundy,Clive Sweet,Kenneth J. Jakeman,James R. Merson,Willard Lew,Matthew A. Williams,Lijun Zhang,Choung U. Kim,Norbert Bischofberger,Ming S. Chen,Dirk B. Mendel +13 more
TL;DR: Results demonstrate that GS 4104 is an orally bioavailable prodrug of GS 4071 in animals and that it has the potential to be an oral agent for the prevention and treatment of influenza A and B virus infections in humans.
Journal ArticleDOI
Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides
Aesop Cho,Oliver L. Saunders,Thomas Butler,Lijun Zhang,Jie Xu,Jennifer E. Vela,Joy Y. Feng,Adrian S. Ray,Choung U. Kim +8 more
TL;DR: The whole cell potency against HCV when R=CN was attributed to inhibition of HCV NS5B polymerase and intracellular concentration of the corresponding nucleoside triphosphate was increased.