M
Matthew A. Williams
Researcher at University of Notre Dame
Publications - 34
Citations - 1265
Matthew A. Williams is an academic researcher from University of Notre Dame. The author has contributed to research in topics: Neuraminidase & Orthomyxoviridae. The author has an hindex of 17, co-authored 34 publications receiving 1240 citations.
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Journal ArticleDOI
Oral Administration of a Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 Protects Mice and Ferrets against Influenza Infection
Dirk B. Mendel,Chun Y. Tai,Paul A. Escarpe,Weixing Li,Robert W. Sidwell,John H. Huffman,Clive Sweet,Kenneth J. Jakeman,James R. Merson,Steven A. Lacy,Willard Lew,Matthew A. Williams,Lijun Zhang,Ming S. Chen,Norbert Bischofberger,Choung U. Kim +15 more
TL;DR: The results indicate that GS 4104 is a novel, orally active antiviral agent with the potential to be used for the prophylaxis and treatment of influenza A and B virus infections.
Journal ArticleDOI
Identification of GS 4104 as an Orally Bioavailable Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071
Weixing Li,Paul A. Escarpe,Eugene J. Eisenberg,Kenneth C. Cundy,Clive Sweet,Kenneth J. Jakeman,James R. Merson,Willard Lew,Matthew A. Williams,Lijun Zhang,Choung U. Kim,Norbert Bischofberger,Ming S. Chen,Dirk B. Mendel +13 more
TL;DR: Results demonstrate that GS 4104 is an orally bioavailable prodrug of GS 4071 in animals and that it has the potential to be an oral agent for the prevention and treatment of influenza A and B virus infections in humans.
Journal ArticleDOI
Characterization of Human Influenza Virus Variants Selected In Vitro in the Presence of the Neuraminidase Inhibitor GS 4071
Chun Y. Tai,Paul A. Escarpe,Robert W. Sidwell,Matthew A. Williams,Willard Lew,Huiwei Wu,Choung U. Kim,Dirk B. Mendel +7 more
TL;DR: Results suggest that although the R292K neuraminidase mutation confers high-level resistance to GS 4071 in vitro, its effect on viral virulence is likely to render this mutation of limited clinical significance.
Journal ArticleDOI
Synthesis of enantiomerically pure diethylenetriaminepentaacetic acid analogs. L-Phenylalanine as the educt for substitution at the central acetic acid
TL;DR: In this article, the enantiospecific synthesis of diethylenetriaminepentaacetic acid (DTPA) analogues from L-phenylalanine via a bis N-alkylation strategy is described.
Journal ArticleDOI
Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site: Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Antiinfluenza Activity.
Choung U. Kim,Willard Lew,Matthew A. Williams,Hua-Kun Liu,Lijun Zhang,S. Swaminathan,Norbert Bischofberger,Min Chen,Dirk B. Mendel,C. Y. Tai,W. G. Laver,Raymond C. Stevens +11 more