N
Norbert Jost
Researcher at University of Szeged
Publications - 78
Citations - 2513
Norbert Jost is an academic researcher from University of Szeged. The author has contributed to research in topics: Repolarization & Internal medicine. The author has an hindex of 23, co-authored 67 publications receiving 2139 citations. Previous affiliations of Norbert Jost include Hungarian Academy of Sciences.
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Journal ArticleDOI
The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation.
Dobromir Dobrev,Adina Friedrich,Niels Voigt,Norbert Jost,Erich Wettwer,Torsten Christ,Michael Knaut,Ursula Ravens +7 more
TL;DR: It is demonstrated that larger basal inward rectifier K+ current in cAF consists of increased IK1 activity and constitutively active IK,ACh, which may represent a new therapeutic target in AF.
Journal ArticleDOI
Restricting Excessive Cardiac Action Potential and QT Prolongation A Vital Role for IKs in Human Ventricular Muscle
Norbert Jost,László Virág,Miklós Bitay,János Takács,Csaba Lengyel,Peter Biliczki,Zsolt Ákos Nagy,Gábor Bogáts,David A. Lathrop,Julius Gy. Papp,András Varró +10 more
TL;DR: The role of IKs in normal human ventricular muscle and in preparations in which both repolarization reserve was attenuated and sympathetic activation was increased by exogenous dofetilide and adrenaline is elucidated, playing an increasingly important role in limiting action potential prolongation.
Journal ArticleDOI
Functional modulation of the transient outward current Ito by KCNE (β-subunits and regional distribution in human non-failing and failing hearts
Susanne Radicke,Diego Cotella,Eva M. Graf,Ulrich Banse,Norbert Jost,András Varró,Gea-Ny Tseng,Ursula Ravens,Erich Wettwer +8 more
TL;DR: KCNE2 induced a unique and prominent 'overshoot' of peak current during recovery from inactivation similar to that described for human I(to) while other KCNE subunits induced little (KCNE4,5) or no overshoot.
Journal ArticleDOI
Ionic mechanisms limiting cardiac repolarization reserve in humans compared to dogs
Norbert Jost,László Virág,Philippe Comtois,Philippe Comtois,Balázs Ördög,Viktoria Szuts,György Seprényi,Miklós Bitay,Zsófia Kohajda,István Koncz,Norbert Nagy,Tamás Szél,János Magyar,Maria Kovacs,László G. Puskás,Csaba Lengyel,Erich Wettwer,Ursula Ravens,Péter P. Nánási,Julius Gy. Papp,András Varró,Stanley Nattel +21 more
TL;DR: Differences in cardiac repolarization‐processes among species are clarified, highlighting the importance of caution when extrapolating results from animal models to man.
Journal ArticleDOI
Polysaccharides; Classification, Chemical Properties, and Future Perspective Applications in Fields of Pharmacology and Biological Medicine (A Review of Current Applications and Upcoming Potentialities)
TL;DR: A review of the most recent updated applications of polysaccharides and their potentialities as alternatives for traditional and conventional therapies is given in this article, where challenges and limitations for polysacchides in pharmaceutical utilities are discussed as well.