N
Norbert Polacek
Researcher at University of Bern
Publications - 81
Citations - 4372
Norbert Polacek is an academic researcher from University of Bern. The author has contributed to research in topics: Ribosome & RNA. The author has an hindex of 33, co-authored 74 publications receiving 3761 citations. Previous affiliations of Norbert Polacek include Innsbruck Medical University & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Non-coding RNAs: hope or hype?
TL;DR: Results are reviewed that show that transcription of non-protein-coding RNA is far more widespread than was previously anticipated and may be evidence of important new biochemical pathways or are merely 'junk' RNA generated by the cell as a by-product of its functional activities.
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tRNA-Derived Fragments Target the Ribosome and Function as Regulatory Non-Coding RNA in Haloferax volcanii
TL;DR: Evidence is presented that tRFs from the halophilic archaeon Haloferax volcanii directly bind to ribosomes, and this tRF functions as ribosome-bound small ncRNA capable of regulating gene expression in H. volCanii under environmental stress conditions probably by fine tuning the rate of protein production.
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Slicing tRNAs to boost functional ncRNA diversity
TL;DR: The biological scope of tRNA-derived fragments ranges from translation control, over RNA silencing, to regulating apoptosis, and thus clearly enlarges the functional repertoire of ncRNA biology.
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Identification of novel non-coding RNAs as potential antisense regulators in the archaeon Sulfolobus solfataricus
Thean-Hock Tang,Norbert Polacek,Marek Zywicki,Marek Zywicki,Harald Huber,Kim Brügger,Roger A. Garrett,Jean Pierre Bachellerie,Alexander Hüttenhofer +8 more
TL;DR: This is the first report of stably expressed antisense RNAs in an archaeal species and it raises the prospect that antisense‐based mechanisms are also used widely in Archaea to regulate gene expression.
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Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan
Markus Schosserer,Nadège Minois,Tina B. Angerer,Manuela Amring,Hanna Dellago,Eva Harreither,Alfonso Calle-Perez,Andreas Pircher,Matthias P. Gerstl,Sigrid Pfeifenberger,Clemens Brandl,Markus Sonntagbauer,Albert Kriegner,Angela Linder,Andreas Weinhäusel,Thomas Mohr,Matthias G. Steiger,Diethard Mattanovich,Mark Rinnerthaler,Thomas Karl,Sunny Sharma,Karl-Dieter Entian,Martin Kos,Michael Breitenbach,Iain B. H. Wilson,Norbert Polacek,Regina Grillari-Voglauer,Lore Breitenbach-Koller,Johannes Grillari +28 more
TL;DR: It is shown that reduced levels of the conserved RNA methyltransferase NSUN5 increase the lifespan and stress resistance in yeast, worms and flies, and linking rRNA-mediated translational regulation to modulation of lifespan, and differential stress response.