N
Norie Tooi
Researcher at Kyoto University
Publications - 7
Citations - 237
Norie Tooi is an academic researcher from Kyoto University. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 6, co-authored 6 publications receiving 220 citations. Previous affiliations of Norie Tooi include Discovery Institute.
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Journal ArticleDOI
Highly efficient differentiation and enrichment of spinal motor neurons derived from human and monkey embryonic stem cells.
Tamaki Wada,Makoto Honda,Itsunari Minami,Norie Tooi,Yuji Amagai,Norio Nakatsuji,Kazuhiro Aiba +6 more
TL;DR: The series of procedures established here, namely neural induction, NSC expansion, sMN differentiation and sMN purification, can provide large quantities of naïve sMNs derived from human and monkey pluripotent stem cells.
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Efficient and Accurate Homologous Recombination in hESCs and hiPSCs Using Helper-dependent Adenoviral Vectors
Emi Aizawa,Yuka Hirabayashi,Yuzuru Iwanaga,Keiichiro Suzuki,Kenji Sakurai,Kenji Sakurai,Miho Shimoji,Kazuhiro Aiba,Tamaki Wada,Norie Tooi,Eihachiro Kawase,Hirofumi Suemori,Norio Nakatsuji,Kohnosuke Mitani +13 more
TL;DR: The results suggest that HDAdV is one of the best methods for efficient and accurate gene targeting in hESCs and hiPSCs and might be especially useful for therapeutic applications.
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Amyotrophic Lateral Sclerosis Model Derived from Human Embryonic Stem Cells Overexpressing Mutant Superoxide Dismutase 1
Tamaki Wada,Sravan K. Goparaju,Norie Tooi,Haruhisa Inoue,Ryosuke Takahashi,Norio Nakatsuji,Kazuhiro Aiba,Kazuhiro Aiba +7 more
TL;DR: An in vitro FALS model from human embryonic stem cells overexpressing either a wild‐type or a mutant SOD1 (G93A) gene is established and is expected to help unravel the disease mechanisms involved in the development of FALS and also lead to potential drug discoveries based on the prevention of neurodegeneration.
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The modeling of Alzheimer's disease by the overexpression of mutant Presenilin 1 in human embryonic stem cells.
Makoto Honda,Itsunari Minami,Norie Tooi,Nobuhiro Morone,Hisae Nishioka,Kengo Uemura,Ayae Kinoshita,John E. Heuser,John E. Heuser,Norio Nakatsuji,Kazuhiro Aiba,Kazuhiro Aiba +11 more
TL;DR: The results suggest that the AD phenotypes, in particular, the electrophysiological abnormality of the synapses in the authors' AD models might be useful for AD research and drug discovery.
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BMS-708163 and Nilotinib restore synaptic dysfunction in human embryonic stem cell-derived Alzheimer's disease models
TL;DR: The results suggest that the human embryonic stem cell-derived AD models developed are promising materials for the discovery of AD drugs that target the expression of pre-synaptic proteins and synaptic function.