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Noriyuki Nishida
Researcher at Nagasaki University
Publications - 118
Citations - 4655
Noriyuki Nishida is an academic researcher from Nagasaki University. The author has contributed to research in topics: Scrapie & PrPSc Proteins. The author has an hindex of 29, co-authored 113 publications receiving 4055 citations. Previous affiliations of Noriyuki Nishida include Centre national de la recherche scientifique & Fukuoka University.
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Journal ArticleDOI
Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene
Suehiro Sakaguchi,Shigeru Katamine,Noriyuki Nishida,Ryozo Moriuchi,Kazuto Shigematsu,Tetsuo Sugimoto,Akira Nakatani,Yasufumi Kataoka,Takeshi Houtani,Susumu Shirabe,Hitoshi Okada,Sumitaka Hasegawa,Tsutomu Miyamoto,Tetsuo Noda +13 more
TL;DR: It is found that homozygous loss of the PrP gene has no deleterious effect on the development of these mice and renders them resistant to prion2, suggesting that PrP plays a role in the long-term survival of Purkinje neurons.
Journal ArticleDOI
Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion
Ryuichiro Atarashi,Katsuya Satoh,Kazunori Sano,Takayuki Fuse,Naohiro Yamaguchi,Daisuke Ishibashi,Takehiro Matsubara,Takehiro Nakagaki,Hitoki Yamanaka,Susumu Shirabe,Masahito Yamada,Hidehiro Mizusawa,Tetsuyuki Kitamoto,Genevieve M Klug,Amelia McGlade,Steven J. Collins,Noriyuki Nishida +16 more
TL;DR: A new PrPSc amplification assay, called real-time quaking-induced conversion (RT-QUIC), which allows the detection of ≥1 fg ofPrPSc in diluted Creutzfeldt-Jakob disease (CJD) brain homogenate, and indicates the promising enhanced diagnostic capacity of RT- QUIC in the antemortem evaluation of suspected CJD.
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Successful Transmission of Three Mouse-Adapted Scrapie Strains to Murine Neuroblastoma Cell Lines Overexpressing Wild-Type Mouse Prion Protein
Noriyuki Nishida,David A. Harris,Didier Vilette,Hubert Laude,Yveline Frobert,Jacques Grassi,Danielle Casanova,Ollivier Milhavet,Sylvain Lehmann +8 more
TL;DR: The results corroborate the hypothesis that the successful transmission of agents ex vivo depends on both expression levels of host PrPC and the sequence of PrPSc and provide a basis for the development of highly susceptible cell lines that could be used in diagnostic and therapeutic approaches to the TSEs.
Journal Article
A mouse prion protein transgene rescues mice deficient for the prion protein gene from Purkinje cell degeneration and demyelination
Noriyuki Nishida,Patrick Tremblay,T. Sugimoto,Kazuto Shigematsu,Susumu Shirabe,Chris Petromilli,Susanne Erpel,Ryota Nakaoke,Ryuichiro Atarashi,T Houtani,Marilyn Torchia,Suehiro Sakaguchi,Stephen J. DeArmond,Stanley B. Prusiner,Shigeru Katamine +14 more
TL;DR: In this article, the authors report torpedo-like axonal swellings associated with residual Purkinje cells in Prnp o/o mice, and demonstrate abnormal myelination in the spinal cord and peripheral nerves.
Journal ArticleDOI
Prion infection impairs the cellular response to oxidative stress
Ollivier Milhavet,Hilary E.M. McMahon,Walid Rachidi,Noriyuki Nishida,Shigeru Katamine,Alain Mangé,Marie Arlotto,Danielle Casanova,Jacqueline Riondel,Alain Favier,Sylvain Lehmann +10 more
TL;DR: This study indicates for the first time that prion infection results in an alteration of the molecular mechanisms promoting cellular resistance to reactive oxygen species and is vital for future therapeutic approaches in transmissible spongiform encephalopathies and the understanding of the function of the prion protein.