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Norman M. Schechter
Researcher at University of Pennsylvania
Publications - 75
Citations - 6942
Norman M. Schechter is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Chymase & Tryptase. The author has an hindex of 44, co-authored 75 publications receiving 6768 citations.
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Journal ArticleDOI
Two types of human mast cells that have distinct neutral protease compositions.
TL;DR: The recognition of human mast cell types with distinct protease compositions suggests a higher level of complexity of humanmast cell-mediated reactions than heretofore appreciated.
Journal Article
Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells.
TL;DR: This study extends the previously reported immunohistochemical distinction between human T and TC mast cells in tissue sections by direct quantitation of chymase and tryptase in dispersed preparations of T andTC mast cells.
Journal ArticleDOI
Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti-chymase antibodies.
Anne-Marie Irani,Timothy R. Bradford,Christopher L. Kepley,Norman M. Schechter,Lawrence B. Schwartz +4 more
TL;DR: An improved immunohistochemical technique for distinguishing human mast cells of the MCT and MCTC types utilizing a biotinylated murine anti-chymase monoclonal antibody (MAb), termed B7, and an alkaline phosphatase-conjugated murines anti-tryptase MAb, termed G3 is developed.
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Reduction of Clofazimine by Mycobacterial Type 2 NADH:Quinone Oxidoreductase A PATHWAY FOR THE GENERATION OF BACTERICIDAL LEVELS OF REACTIVE OXYGEN SPECIES
Takahiro Yano,Sacha Kassovska-Bratinova,J. Shin Teh,Jeffrey D. Winkler,Kevin Sullivan,André K. Isaacs,Norman M. Schechter,Harvey Rubin +7 more
TL;DR: A pathway for a continuous and high rate of reactive oxygen species production in Mycobacterium smegmatis treated with CFZ and a CFZ analog is described as well as evidence that cell death produced by these agents are related to the production of these radical species.
Journal ArticleDOI
Squamous Cell Carcinoma Antigen 2 Is a Novel Serpin That Inhibits the Chymotrypsin-like Proteinases Cathepsin G and Mast Cell Chymase
Charles Schick,Yoshiro Kamachi,Allison J. Bartuski,Sule Cataltepe,Norman M. Schechter,Philip A. Pemberton,Gary A. Silverman +6 more
TL;DR: Recombinant SCCA2 was most effective against two chymotrypsin-like proteinases from inflammatory cells, but was ineffective against papain-like cysteine proteinases.