N
Numana Bhat
Researcher at University of Massachusetts Medical School
Publications - 3
Citations - 537
Numana Bhat is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 3, co-authored 3 publications receiving 435 citations.
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Journal ArticleDOI
Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid
Joseph E. Conlon,Dara Burdette,Shrutie Sharma,Numana Bhat,Mikayla R. Thompson,Zhaozhao Jiang,Vijay A. K. Rathinam,Brian G. Monks,Tengchuan Jin,T. Sam Xiao,Stefanie N. Vogel,Russell E. Vance,Katherine A. Fitzgerald +12 more
TL;DR: Stimulator of IFN gene (STING) is identified as a direct receptor for DMXAA leading to TANK-binding kinase 1 and IFN regulatory factor 3 signaling, revealing an unexpected species-specific role for STING as a receptor for an anticancer drug.
Journal ArticleDOI
Recognition of cytosolic DNA by cGAS and other STING-dependent sensors.
TL;DR: The recent discovery of the cGAS‐cGAMP second messenger pathway as well as IFI16 and additional sensors collectively provide critical insights into the molecular basis behind the sensing of cytoplasmic DNA.
Journal ArticleDOI
Human Gene-Centered Transcription Factor Networks for Enhancers and Disease Variants
Juan I. Fuxman Bass,Nidhi Sahni,Shaleen Shrestha,Aurian P. García-González,Akihiro Mori,Numana Bhat,Song Yi,David E. Hill,Marc Vidal,Albertha J.M. Walhout,Albertha J.M. Walhout +10 more
TL;DR: eY1H assays are established as a powerful addition to the toolkit of mapping human GRNs and for the high-throughput characterization of genomic variants that are rapidly being identified by genome-wide association studies.