Nuria Acero

TL;DR: New compounds, structurally related to the potent protein kinase C inhibitor staurosporine, with a bisindolylpyrazolone framework and substituted on the pyrazol one nitrogens with N,N-dialkylaminoalkyl side chain, were synthesized and evaluated for growth-inhibitory properties in several human cell lines.

TL;DR: Differences between in vitro and in cell culture results evidence the interaction among the phenolic compounds of the extract, and showed a significant inhibitory effect on the xanthine/xanthine oxidase system.

TL;DR: Monofuryl 1o has been synthesized and is one of the most active compounds against CDK1 of this series and has been rationalized on the basis of the proposed binding mode for compound 1a.

TL;DR: A series of mono and bisintercalators based on the 5,8-dihydrobenz[de]imidazo[4,5-g]isoquinoline-4,6-dione system were synthesized and evaluated for growth inhibitory properties in several human cell lines, showing that they behave as DNA intercalators.

TL;DR: This review summarizes the anticancer activities shown by natural chalcones and the SAR and describes how different chemical moiety modifications could lead them to be therapeutically useful in the treatment of cancer.