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Antonio J. León-González
Researcher at University of Córdoba (Spain)
Publications - 38
Citations - 1050
Antonio J. León-González is an academic researcher from University of Córdoba (Spain). The author has contributed to research in topics: Prostate cancer & Oxidative stress. The author has an hindex of 12, co-authored 36 publications receiving 718 citations. Previous affiliations of Antonio J. León-González include Sofia University & University of Seville.
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Pro-oxidant activity of polyphenols and its implication on cancer chemoprevention and chemotherapy.
TL;DR: The aim of the present review is to present the main evidences of the pro-oxidant-related cytotoxic activity of naturally occurring polyphenols and their underlying mechanisms.
Journal ArticleDOI
Pro-Oxidant Natural Products as Anticancer Agents
Carmen Martín-Cordero,Antonio J. León-González,José Manuel Calderón-Montaño,Estefanía Burgos-Morón,Miguel López-Lázaro +4 more
TL;DR: An overview of natural products with pro-oxidant and anticancer activities, with special focus on plant secondary metabolites, and discusses their possible use as cancer chemotherapeutic agents.
Journal ArticleDOI
Endothelial Microparticles From Acute Coronary Syndrome Patients Induce Premature Coronary Artery Endothelial Cell Aging and Thrombogenicity: Role of the Ang II/AT1 Receptor/NADPH Oxidase-Mediated Activation of MAPKs and PI3-Kinase Pathways
Malak Abbas,Laurence Jesel,Cyril Auger,Lamia Amoura,Nathan Messas,Guillaume Manin,Cordula Rumig,Antonio J. León-González,Thaís P. Ribeiro,Grazielle C. Silva,Raghida Abou-Merhi,Eva Hamade,Markus Hecker,Yannick Georg,Nabil Chakfe,Patrick Ohlmann,Valérie B. Schini-Kerth,Florence Toti,Olivier Morel +18 more
TL;DR: Findings indicate that endothelial-derived MPs from ACS patients induce premature endothelial senescence under atheroprone low shear stress and thrombogenicity through angiotensin II–induced redox-sensitive activation of mitogen-activated protein kinases and phosphoinositide 3-kinase/Akt.
Journal ArticleDOI
Dysregulation of the splicing machinery is directly associated to aggressiveness of prostate cancer.
Juan M. Jiménez-Vacas,Vicente Herrero-Aguayo,Antonio J. Montero-Hidalgo,Enrique Gómez-Gómez,Antonio C Fuentes-Fayos,Antonio J. León-González,Prudencio Sáez-Martínez,Emilia Alors-Perez,Sergio Pedraza-Arevalo,Teresa González-Serrano,Oscar Reyes,Ana Martínez-López,Rafael Sánchez-Sánchez,Sebastián Ventura,Elena M. Yubero-Serrano,M.J. Requena-Tapia,Justo P. Castaño,Manuel D. Gahete,Raúl M. Luque +18 more
TL;DR: The results demonstrate that the spliceosome is drastically altered in PCa wherein SNRNP200, SRSF3 and SRRM1 could represent attractive novel diagnostic/prognostic and therapeutic targets for PCa and CRPC.
Journal ArticleDOI
Chalcones as Promising Lead Compounds on Cancer Therapy
Antonio J. León-González,Nuria Acero,Dolores Muñoz-Mingarro,I. Navarro,Carmen Martín-Cordero +4 more
TL;DR: This review summarizes the anticancer activities shown by natural chalcones and the SAR and describes how different chemical moiety modifications could lead them to be therapeutically useful in the treatment of cancer.