N
Nurit Keinan
Researcher at Ben-Gurion University of the Negev
Publications - 11
Citations - 1549
Nurit Keinan is an academic researcher from Ben-Gurion University of the Negev. The author has contributed to research in topics: Voltage-dependent anion channel & VDAC1. The author has an hindex of 8, co-authored 10 publications receiving 1343 citations.
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VDAC, a multi-functional mitochondrial protein regulating cell life and death.
TL;DR: What is known about the VDAC channel in terms of its structure, relevance to ATP rationing, Ca(2+) homeostasis, protection against oxidative stress, regulation of apoptosis, involvement in several diseases and its role in the action of different drugs is reviewed.
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The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins.
Salah Abu-Hamad,Nir Arbel,Doron Calo,Laetitia Arzoine,Adrian Israelson,Nurit Keinan,Ronit Ben-Romano,Orr Friedman,Varda Shoshan-Barmatz +8 more
TL;DR: Results show VDAC1 to be a component of the apoptosis machinery and offer new insight into the mechanism of cytochrome c release and how anti-apoptotic proteins regulate apoptosis and promote tumor cell survival.
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Oligomerization of the Mitochondrial Protein Voltage-Dependent Anion Channel Is Coupled to the Induction of Apoptosis
TL;DR: It is proposed that VDAC oligomerization is involved in mitochondrion-mediated apoptosis and may represent a general mechanism common to numerous apoptogens acting via different initiating cascades, and offers a therapeutic strategy for combating cancers and neurodegenerative diseases.
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Uncovering the role of VDAC in the regulation of cell life and death
TL;DR: Insight is provided into the central role of VDAC function in the regulation of mitochondria-mediated apoptosis and, as such, its potential as a rational target for new therapeutics is emphasized.
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Apoptosis is regulated by the VDAC1 N-terminal region and by VDAC oligomerization: release of cytochrome c, AIF and Smac/Diablo.
TL;DR: Findings suggest that VDAC1 is involved in the release of not only cytochrome c but also of Smac/Diablo and AIF, and it is demonstrated that apoptosis induction is associated with VDac oligomerization, as revealed by chemical cross-linking and monitoring in living cells using Bioluminescence Resonance Energy Transfer.