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O. Dumont

Researcher at French Institute of Health and Medical Research

Publications -  14
Citations -  1059

O. Dumont is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Polyunsaturated fatty acid & Docosahexaenoic acid. The author has an hindex of 14, co-authored 14 publications receiving 1042 citations.

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Alterations in the Fatty Acid Composition of Rat Brain Cells (Neurons, Astrocytes, and Oligodendrocytes) and of Subcellular Fractions (Myelin and Synaptosomes) Induced by a Diet Devoid of n‐3 Fatty Acids

TL;DR: Fatty acid analysis in isolated cellular and subcellular material from sunflower‐fed animals showed that the total amount of unsaturated fatty acids was not reduced in any cellular or sub cellular fraction (except in 60‐day‐old rat neurons).
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Dietary linoleic acid and polyunsaturated fatty acids in rat brain and other organs. Minimal requirements of linoleic acid.

TL;DR: In several organs (muscle, lung, kidney, liver, heart) as well as in myelin, very low levels of dietary linoleic acid led to an increase in 20∶5n−3, and accumulation of docosapentaenoic acid was the most direct and specific consequence of increasing amounts of dietary 18∶2n−6.
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Δ6 desaturase in brain and liver during development and aging

TL;DR: During pre- and postnatal development, Δ6 desaturase in brain and liver decreased dramatically up to postnatal day 21 and remained nearly constant thereafter and decreased with age from then on.
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Function of dietary polyunsaturated fatty acids in the nervous system.

TL;DR: There is a linear relationship between brain content of (n-3) acids and the content of the diet up to the point where alpha-linolenic levels reach 200 mg for 100 g food intake, and beyond that level there is a plateau, but for the other organs, such as the liver, there is merely an abrupt change in slope and not a plateau.
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Recovery of altered fatty acid composition induced by a diet devoid of n-3 fatty acids in myelin, synaptosomes, mitochondria, and microsomes of developing rat brain.

TL;DR: In all fractions examined, when sunflower oil was replaced by soya oil in 15‐day‐old pups the recovery started from the very first day but lasted more than 2 months, and a delay was found for myelin recovery, starting only from the 25th day.