O
Oezge Canli
Researcher at Technische Universität München
Publications - 2
Citations - 920
Oezge Canli is an academic researcher from Technische Universität München. The author has contributed to research in topics: Carcinogenesis & IκB kinase. The author has an hindex of 1, co-authored 1 publications receiving 856 citations.
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Journal ArticleDOI
gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis
Julia Bollrath,Toby J. Phesse,Vivian A von Burstin,Tracy L Putoczki,Moritz Bennecke,Trudie Bateman,Tim Nebelsiek,Therese Lundgren-May,Oezge Canli,Sarah Schwitalla,Vance Matthews,Roland M. Schmid,Thomas Kirchner,Melek C. Arkan,Matthias Ernst,Florian R. Greten +15 more
TL;DR: A link comprising the gp130/Stat3 transcription factor signaling axis is established comprising the common tumor cell-autonomous mechanism that bridges chronic inflammation to tumor promotion in colitis-associated cancer models.
Journal ArticleDOI
IKKα Promotes Intestinal Tumorigenesis by Limiting Recruitment of M1-like Polarized Myeloid Cells.
Serkan Ismail Göktuna,Oezge Canli,Julia Bollrath,Alexander A. Fingerle,David Horst,Michaela A. Diamanti,Charles K. Pallangyo,Moritz Bennecke,Tim Nebelsiek,Arun K. Mankan,Roland Lang,David Artis,Yinling Hu,T Patzelt,Jürgen Ruland,Thomas Kirchner,Maketo M. Taketo,Alain Chariot,Melek C. Arkan,Florian R. Greten +19 more
TL;DR: Göktuna et al. as mentioned in this paper identified IKKα as a central regulator of a tumoricidal microenvironment during intestinal carcinogenesis and showed that mice deficient in IKK α kinase activity are largely protected from intestinal tumorigenesis due to enhanced recruitment of IFNγ-expressing M1-like myeloid cells.