M
Melek C. Arkan
Researcher at Technische Universität München
Publications - 20
Citations - 5421
Melek C. Arkan is an academic researcher from Technische Universität München. The author has contributed to research in topics: IκB kinase & Intestinal mucosa. The author has an hindex of 15, co-authored 17 publications receiving 4841 citations. Previous affiliations of Melek C. Arkan include University of California, San Diego & German Cancer Research Center.
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Journal ArticleDOI
IKK-beta links inflammation to obesity-induced insulin resistance.
Melek C. Arkan,Andrea L. Hevener,Florian R. Greten,Shin Maeda,Zhi-Wei Li,Jeffrey M. Long,Anthony Wynshaw-Boris,Giuseppe Poli,Jerrold M. Olefsky,Michael Karin +9 more
TL;DR: The importance of liver cell IKK-β in hepatic insulin resistance and the central role of myeloid cells in development of systemic insulin resistance are demonstrated and it is suggested that inhibition of Ikk-β, especially in myeloids cells, may be used to treat insulin resistance.
Journal ArticleDOI
Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties
Sarah Schwitalla,Alexander A. Fingerle,Patrizia Cammareri,Tim Nebelsiek,Serkan Ismail Göktuna,Paul Ziegler,Özge Canli,Jarom Heijmans,David J. Huels,Guenievre Moreaux,Rudolf A. Rupec,Markus Gerhard,Roland M. Schmid,Nick Barker,Hans Clevers,Roland Lang,Jens Neumann,Thomas Kirchner,Makoto Mark Taketo,Gijs R. van den Brink,Owen J. Sansom,Melek C. Arkan,Florian R. Greten +22 more
TL;DR: This work demonstrates that NF-κB modulates Wnt signaling and shows that IEC-specific ablation of RelA/p65 retards crypt stem cell expansion and highlights the importance of inflammatory signaling for dedifferentiation and generation of tumor-initiating cells in vivo.
Journal ArticleDOI
gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis
Julia Bollrath,Toby J. Phesse,Vivian A von Burstin,Tracy L Putoczki,Moritz Bennecke,Trudie Bateman,Tim Nebelsiek,Therese Lundgren-May,Oezge Canli,Sarah Schwitalla,Vance Matthews,Roland M. Schmid,Thomas Kirchner,Melek C. Arkan,Matthias Ernst,Florian R. Greten +15 more
TL;DR: A link comprising the gp130/Stat3 transcription factor signaling axis is established comprising the common tumor cell-autonomous mechanism that bridges chronic inflammation to tumor promotion in colitis-associated cancer models.
Journal ArticleDOI
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta.
Florian R. Greten,Florian R. Greten,Melek C. Arkan,Melek C. Arkan,Julia Bollrath,Li-Chung Hsu,Jason Goode,Cornelius Miething,Serkan Ismail Göktuna,Michael Neuenhahn,Joshua Fierer,Stephan Paxian,Nico van Rooijen,Yajun Xu,Timothy D. Ocain,Bruce Jaffee,Dirk H. Busch,Justus Duyster,Roland M. Schmid,Lars Eckmann,Michael Karin +20 more
TL;DR: An unanticipated role for IKKbeta-dependent NF-kappaB signaling in the negative control of IL-1beta production is unraveled and potential complications of long-term IKK beta inhibition are highlighted.
Journal ArticleDOI
High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity
Manon D. Schulz,Çiğdem Atay,Jessica Heringer,Franziska K. Romrig,Sarah Schwitalla,Begüm Aydin,Paul K. Ziegler,Julia Varga,W Reindl,Claudia Pommerenke,Gabriela Salinas-Riester,Andreas Böck,Carl Alpert,Michael Blaut,Sara C. Polson,Lydia Brandl,Thomas Kirchner,Florian R. Greten,Shawn W. Polson,Melek C. Arkan +19 more
TL;DR: It is demonstrated that an HFD promotes tumour progression in the small intestine of genetically susceptible, K-rasG12Dint, mice independently of obesity, and this data underscore the importance of the reciprocal interaction between host and environmental factors in selecting a microbiota that favours carcinogenesis.