O
Ole J. Halvorsen
Researcher at University of Bergen
Publications - 76
Citations - 3352
Ole J. Halvorsen is an academic researcher from University of Bergen. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 24, co-authored 72 publications receiving 3034 citations. Previous affiliations of Ole J. Halvorsen include Haukeland University Hospital & Vanderbilt University.
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Journal ArticleDOI
EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
Ingeborg M. Bachmann,Ole J. Halvorsen,Karin Collett,Ingunn M. Stefansson,Oddbjørn Straume,Svein A. Haukaas,Helga B. Salvesen,Arie P. Otte,Lars A. Akslen +8 more
TL;DR: In this paper, the authors examined EZH2 expression and its association with tumor cell proliferation and other tumor markers, clinical features, and prognosis in cutaneous melanoma and cancers of the endometrium, prostate, and breast.
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A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancer.
TL;DR: Novel data are presented that unravel the importance of epithelial to mesenchymal transition for prostate cancer progression, and demonstration of a switch from E-cadherin to N-cADherin expression could have significant effect on the care of prostate cancer patients is demonstrated.
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Concordance between Gleason scores of needle biopsies and radical prostatectomy specimens : a population-based study
Rune Kvåle,Bjørn Møller,Rolf Wahlqvist,Sophie D. Fosså,Aasmund Berner,Christer Busch,Anne E. Kyrdalen,Aud Svindland,Trond Viset,Ole J. Halvorsen +9 more
TL;DR: To study the concordance between the Gleason scores of needle biopsies and radical prostatectomy specimens in a population‐based registry, it is necessary to identify preoperative clinical factors that predict upgrading from a Gleason score of ≤6 in the biopsy to ≥7 in the RP specimen.
Journal Article
Combined loss of PTEN and p27 expression is associated with tumor cell proliferation by Ki-67 and increased risk of recurrent disease in localized prostate cancer.
TL;DR: The findings strongly support the importance of PTEN and p27 for the progression of human prostate cancer because loss ofPTEN/p27 expression was associated with adverse pathological parameters, tumor cell proliferation, and increased risk of recurrence.
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Genome-wide profiling of histone h3 lysine 4 and lysine 27 trimethylation reveals an epigenetic signature in prostate carcinogenesis.
Xisong Ke,Yi Qu,Kari Rostad,Wen-Cheng Li,Wen-Cheng Li,Biaoyang Lin,Ole J. Halvorsen,Svein A. Haukaas,Svein A. Haukaas,Inge Jonassen,Kjell Petersen,Naomi Goldfinger,Varda Rotter,Lars A. Akslen,Lars A. Akslen,Anne Margrete Øyan,Anne Margrete Øyan,Karl-Henning Kalland,Karl-Henning Kalland +18 more
TL;DR: The data indicate an H3K4me3/H3K27me3 epigenetic signature of prostate carcinogenesis, which contributes to an overall understanding of coordinated regulation of gene expression in cancer.