O
Olena Karatsai
Researcher at Nencki Institute of Experimental Biology
Publications - 11
Citations - 77
Olena Karatsai is an academic researcher from Nencki Institute of Experimental Biology. The author has contributed to research in topics: Arginine & Endoplasmic reticulum. The author has an hindex of 3, co-authored 10 publications receiving 33 citations. Previous affiliations of Olena Karatsai include National Academy of Sciences of Ukraine.
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Polyphenolic Compounds of Crataegus Berry, Leaf, and Flower Extracts Affect Viability and Invasive Potential of Human Glioblastoma Cells.
TL;DR: In this paper, the effects of polyphenol-rich extracts of berries, leaves, and flowers of six Crataegus species on the viability and invasive potential on the highly aggressive human glioblastoma U87MG cell line were evaluated.
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Myosin VI in the nucleus of neurosecretory PC12 cells: Stimulation-dependent nuclear translocation and interaction with nuclear proteins*
Lukasz Majewski,Jolanta Nowak,Magdalena Sobczak,Olena Karatsai,Serhiy Havrylov,Robert Lenartowski,Małgorzata Suszek,Marta Lenartowska,Maria Jolanta Redowicz +8 more
TL;DR: An increase in nuclear localization of MVI upon cell stimulation, and identification of potential nuclear localization (NLS) and nuclear export (NES) signals within MVI heavy chain are shown to be functional as the MVI nuclear presence was affected by the inhibitors of nuclear import and export.
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Combinatory Treatment of Canavanine and Arginine Deprivation Efficiently Targets Human Glioblastoma Cells via Pleiotropic Mechanisms
TL;DR: The findings provide a strong rationale for further developing the proposed modality based on canavanine and arginine deprivation as a potential antiglioblastoma metabolic therapy independent of the blood–brain barrier.
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Synergistic Interactions of 5-Fluorouracil with Inhibitors of Protein Kinase CK2 Correlate with p38 MAPK Activation and FAK Inhibition in the Triple-Negative Breast Cancer Cell Line
Patrycja Wińska,Olena Karatsai,Monika Staniszewska,Mirosława Koronkiewicz,K. Chojnacki,Maria Jolanta Redowicz +5 more
TL;DR: The synergistic interactions observed in MDA-MB-231 correlated with an activation of p38 MAPK, inhibition of FAK, increased expression of apoptogenic markers, prolongation of S-phase of cell cycle, and destabilization of actin network.
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Formation of Aberrant Myotubes by Myoblasts Lacking Myosin VI Is Associated with Alterations in the Cytoskeleton Organization, Myoblast Adhesion and Fusion.
Lilya Lehka,Malgorzata Topolewska,Dominika Wojton,Olena Karatsai,Paloma Alvarez-Suarez,Paweł Pomorski,Maria Jolanta Redowicz +6 more
TL;DR: The data indicate that in the absence of MVI, the mechanisms controlling cytoskeleton organization, as well as myoblast adhesion and fusion, are dysregulated, leading to the formation of aberrant myotubes.