O
Olga Ignatovich
Researcher at Laboratory of Molecular Biology
Publications - 17
Citations - 356
Olga Ignatovich is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Binding selectivity & Chemical specificity. The author has an hindex of 4, co-authored 17 publications receiving 353 citations. Previous affiliations of Olga Ignatovich include University of Montpellier.
Papers
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Journal ArticleDOI
Sequence and evolution of the human germline V lambda repertoire.
Samuel C. Williams,Jean-Pol Frippiat,Jean-Pol Frippiat,I M Tomlinson,I M Tomlinson,Olga Ignatovich,Olga Ignatovich,Marie-Paule Lefranc,Marie-Paule Lefranc,Greg Winter,Greg Winter +10 more
TL;DR: This analysis indicates that there are approximately 30 functional V lambda genes, depending on the haplotype, that belong to ten V lambda families that predominate in species that express mainly lambda light chains.
Patent
Ligands that have binding specificity for vegf and/or egfr and methods of use therefor
TL;DR: In this article, ligands that have binding specificity for vascular endothelial growth factor (VEGF), for epidermal growth factor receptor (EGFR), or for VEGF and EGFR were discussed.
Patent
Dual specific ligands with increased serum half-life
TL;DR: In this article, a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificity and a complementary or non-complementary variable domain with a second binding specificity was proposed.
Patent
Ligands that bind a receptor
TL;DR: In this article, the concept of single variable domains (SVDs) was introduced and applied to ligands that have binding specificity for a receptor, such as a cell surface receptor, and the ligand inhibits the activity of the receptor.
Patent
Composition and method for treating inflammatory disorder
Olga Ignatovich,Rudolf M T De Wildt,Benjamin P. Woolven,Steven Grant,Philip Jones,Amrik Basran,Neil D. Brewis,Ian M. Tomlinson,Philip Anthony Jennings,Anthony Gerard Doyle +9 more
TL;DR: In this article, the authors present methods of treatment of rheumatoid arthritis using antibody polypeptide constructs including single domain antibody ligands and dual specific ligands, compositions and methods of making and using such ligands.