Olga Kovalchuk

TL;DR: The mechanistic link of miRNAome deregulation and the multidrug-resistant phenotype of MCF-7/DOX cells was evidenced by a remarkable correlation between specific miRNA expression and corresponding changes in protein levels of their targets, specifically those ones that have a documented role in cancer drug resistance.

TL;DR: The results suggest that dysregulated miRNA expression may underlie the abnormal functioning of critical cellular processes associated with the cisplatin‐resistant phenotype.

TL;DR: The genetic and epigenetic mechanisms of MN formation after various clastogenic and aneugenic effects on cell division and cell cycle are described and individual sensitivity to MN formation due to single gene polymorphisms is discussed.

TL;DR: Sperm DNA was hypermethylated in mice breathing ambient relative to HEPA-filtered air and this change persisted following removal from the environmental exposure, and increased germ-line DNA mutation frequencies may cause population-level changes in genetic composition and disease.

TL;DR: A threefold increase in homologous recombination frequency in both infected and non-infected tissue of tobacco plants infected with either tobacco mosaic virus or oilseed rape mosaic virus is reported, indicating the existence of a systemic recombination signal that also results in an increased frequency of meiotic and/or inherited late somatic recombination.