O
Olivier Roy
Researcher at University of Auvergne
Publications - 33
Citations - 844
Olivier Roy is an academic researcher from University of Auvergne. The author has contributed to research in topics: Peptoid & Side chain. The author has an hindex of 13, co-authored 32 publications receiving 731 citations. Previous affiliations of Olivier Roy include Centre national de la recherche scientifique & Blaise Pascal University.
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The click triazolium peptoid side chain: a strong cis-amide inducer enabling chemical diversity.
TL;DR: It is reported for the first time a positively charged triazolium-type side chain that does not compromise diversity and exhibits the best ability reported to date for inducing the cis conformation.
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Selectivity among two lectins: probing the effect of topology, multivalency and flexibility of "clicked" multivalent glycoclusters.
Samy Cecioni,Samy Cecioni,Sophie Faure,Ulrich Darbost,I. Bonnamour,Hélène Parrot-Lopez,Olivier Roy,Claude Taillefumier,Michaela Wimmerová,Jean-Pierre Praly,Anne Imberty,Sébastien Vidal +11 more
TL;DR: The results obtained illustrate the influence of the scaffold's geometry on the affinity towards the lectin and also on the relative potency in comparison with a monovalent galactoside reference probe.
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The tert-butyl side chain: a powerful means to lock peptoid amide bonds in the cis conformation.
Olivier Roy,Cécile Caumes,Yannick J. Esvan,Claude Didierjean,Sophie Faure,Claude Taillefumier +5 more
TL;DR: The very simple sterically hindered tert-butyl side chain exerts complete control over the peptoid amide geometry which only exists in the cis conformation.
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Cyclic beta-peptoids.
TL;DR: The first synthesis of functionalized beta-peptoid macrocycles is reported, which constitute novel promising templates for multimeric ligation of biologically active ligands.
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Homogeneous and Robust Polyproline Type I Helices from Peptoids with Nonaromatic α-Chiral Side Chains.
Olivier Roy,Geoffrey Dumonteil,Sophie Faure,Laurent Jouffret,Alexandre Kriznik,Claude Taillefumier +5 more
TL;DR: The synthesis and detailed conformational analysis of a series of (S)-N-(1-tert-butylethyl)glycine (Ns1tbe) peptoid homo-oligomers are reported, which are the first for any conformationally homogeneous helical peptoids containing only α-chiral aliphatic side chains.