O
Om Silakari
Researcher at Punjabi University
Publications - 69
Citations - 3303
Om Silakari is an academic researcher from Punjabi University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 23, co-authored 53 publications receiving 2426 citations.
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Journal ArticleDOI
The therapeutic journey of benzimidazoles: a review.
Yogita Bansal,Om Silakari +1 more
TL;DR: In the present review, various derivatives of benzimidazole with different pharmacological activities are described on the basis of substitution pattern around the nucleus with an aim to help medicinal chemists for developing an SAR on benzimdazole derived compounds for each activity.
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Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view.
Navriti Chadha,Om Silakari +1 more
TL;DR: An overview of the chemistry, biology, and toxicology of indoles focusing on their application as drugs is provided to corroborate the information available on the natural indole alkaloids, indole based FDA approved drugs and clinical trial candidates having diverse therapeutic implementations.
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Flavones: An important scaffold for medicinal chemistry
TL;DR: The present review gives detail about the structural requirement of flavone derivatives for various pharmacological activities and may provide an opportunity to scientists of medicinal chemistry discipline to design selective, optimize as well as poly-functional flavones derivatives for the treatment of multi-factorial diseases.
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Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection.
TL;DR: A spectrum of strategies to design AChE inhibitors used in the Alzheimer therapy is given, which shows the most viable therapeutic target for the symptomatic treatment of AD.
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Coumarin hybrids as novel therapeutic agents.
TL;DR: The present review compiles research reports on development of different coumarin hybrids, classify these on the basis of their therapeutic uses and propose structure-activity relationships to help medicinal chemist in designing and synthesizing novel and potent hybrid compounds for the treatment of different disorders.