Journal ArticleDOI
The therapeutic journey of benzimidazoles: a review.
Yogita Bansal,Om Silakari +1 more
TLDR
In the present review, various derivatives of benzimidazole with different pharmacological activities are described on the basis of substitution pattern around the nucleus with an aim to help medicinal chemists for developing an SAR on benzimdazole derived compounds for each activity.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2012-11-01. It has received 584 citations till now. The article focuses on the topics: Benzimidazole.read more
Citations
More filters
Journal ArticleDOI
Resistance of Gram-Negative Bacteria to Current Antibacterial Agents and Approaches to Resolve It
TL;DR: Research efforts have been made to meet the urgent need for new treatments; some have succeeded to yield activity against resistant Gram-negative bacteria by deactivating the mechanism of resistance, like the action of the β-lactamase Inhibitor antibiotic adjuvants.
Journal ArticleDOI
Iridium-Catalyzed C–H Borylation of Heteroarenes: Scope, Regioselectivity, Application to Late-Stage Functionalization, and Mechanism
TL;DR: One-pot functionalizations are reported of the hetero Daryl boronate esters formed in situ, demonstrating the usefulness of the reported methodology for the synthesis of complex heteroaryl structures.
Journal ArticleDOI
Comprehensive Review in Current Developments of Benzimidazole-Based Medicinal Chemistry.
TL;DR: This work systematically gives a comprehensive review in current developments of benzimidazole‐based compounds in the whole range of medicinal chemistry as anticancer, antibacterial, antifungal, anti‐inflammatory, analgesic agents, anti-HIV, antioxidant, anticonvulsant, antitubercular, antidiabetic, antileishmanial, antihistaminic, antimalarial agents, and other medicinal agents.
Journal ArticleDOI
Coumarin hybrids as novel therapeutic agents.
TL;DR: The present review compiles research reports on development of different coumarin hybrids, classify these on the basis of their therapeutic uses and propose structure-activity relationships to help medicinal chemist in designing and synthesizing novel and potent hybrid compounds for the treatment of different disorders.
Journal ArticleDOI
Suzuki-Miyaura Cross-Coupling of Unprotected, Nitrogen-Rich Heterocycles: Substrate Scope and Mechanistic Investigation
TL;DR: The Suzuki-Miyaura cross-coupling of unprotected, nitrogen-rich heterocycles using precatalysts P1 or P2 is reported and the mechanism behind the inhibitory effect of unprotected azoles on Pd-catalyzed cross- coupling reactions is described.
References
More filters
Journal ArticleDOI
Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
Journal ArticleDOI
Points of control in inflammation
TL;DR: The non-inflammatory state does not arise passively from an absence of inflammatory stimuli; rather, maintenance of health requires the positive actions of specific gene products to suppress reactions to potentially inflammatory stimuli that do not warrant a full response.
Journal ArticleDOI
Inflammation 2010: new adventures of an old flame.
TL;DR: Inflammation is an essential immune response that enables survival during infection or injury and maintains tissue homeostasis under a variety of noxious conditions but comes at the cost of a transient decline in tissue function, which can in turn contribute to the pathogenesis of diseases of alteredHomeostasis.
Journal ArticleDOI
Mice lacking melanin-concentrating hormone are hypophagic and lean
Masako Shimada,Nicholas A. Tritos,Bradford B. Lowell,Jeffrey S. Flier,Eleftheria Maratos-Flier +4 more
TL;DR: MCH is a critical regulator of feeding and energy balance which acts downstream of leptin and the melanocortin system, and that deletion of a gene encoding a single orexigenic peptide can result in leanness.
Journal ArticleDOI
Anti-inflammatory Agents: Present and Future
TL;DR: The new era of anti-inflammatory agents includes "biologicals" such as anticytokine therapies and small molecules that block the activity of kinases and small RNAs.
Related Papers (5)
Structure activity relationship (SAR) study of benzimidazole scaffold for different biological activities: A mini-review
Geeta Yadav,Swastika Ganguly +1 more