O
Omar José
Researcher at National Autonomous University of Mexico
Publications - 11
Citations - 365
Omar José is an academic researcher from National Autonomous University of Mexico. The author has contributed to research in topics: Acrosome reaction & Sperm. The author has an hindex of 7, co-authored 11 publications receiving 281 citations.
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Journal ArticleDOI
Intracellular pH in sperm physiology.
Takuya Nishigaki,Omar José,Ana Laura González-Cota,Francisco J. Romero,Claudia L. Treviño,Alberto Darszon +5 more
TL;DR: This review briefly summarizes the key components involved in pHi regulation, their characteristics and participation in fundamental sperm functions such as motility, maturation and the acrosome reaction.
Journal ArticleDOI
Acrosome Reaction and Ca2+ Imaging in Single Human Spermatozoa: New Regulatory Roles of [Ca2+]i
Claudia Sánchez-Cárdenas,Martha Rocio Servín-Vences,Omar José,Claudia L. Treviño,Arturo Hernández-Cruz,Alberto Darszon +5 more
TL;DR: It is shown that FM4-64, a fluorescent dye used to follow exocytosis, reliably reports AR progression induced by ionomycin and progesterone in human spermatozoa, and uncover new AR features related to [Ca2+]i.
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Human spermatozoa possess a calcium-dependent chloride channel that may participate in the acrosomal reaction
TL;DR: This work presents the first evidence for the presence of calcium‐dependent chloride channels (CaCCs) in human spermatozoa; they could be constituted by TMEM16.
Journal ArticleDOI
Acrosomal alkalization triggers Ca2+ release and acrosome reaction in mammalian spermatozoa.
Julio C. Chávez,José L. De la Vega-Beltrán,Omar José,Paulina Torres,Takuya Nishigaki,Claudia L. Treviño,Alberto Darszon +6 more
TL;DR: The findings suggest that alkalization of the acrosome is critical step for Ca2+ release from the acosome that leads to the acOSome reaction, and this correlates with spontaneous AR in both mouse and human sperm.
Journal ArticleDOI
Recombinant human ZP3-induced sperm acrosome reaction: evidence for the involvement of T- and L-type voltage-gated calcium channels.
Omar José,Oscar Hernández-Hernández,Mayel Chirinos,María Elena González-González,Fernando Larrea,Angélica Almanza,Angélica Almanza,Ricardo Felix,Alberto Darszon,Claudia L. Treviño +9 more
TL;DR: Rec recombinant human ZP3 produced in baculovirus-infected Sf9 cells is used to investigate the involvement of Ca(V) channels in the human sperm AR, and overall findings suggest that Ca(v)1 and Ca( V)3 channels participate in human spermAR.