O
Oren Caspi
Researcher at Rappaport Faculty of Medicine
Publications - 46
Citations - 5813
Oren Caspi is an academic researcher from Rappaport Faculty of Medicine. The author has contributed to research in topics: Embryonic stem cell & Stem cell. The author has an hindex of 20, co-authored 38 publications receiving 5341 citations. Previous affiliations of Oren Caspi include University of California, San Diego & Rambam Health Care Campus.
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Journal ArticleDOI
Modelling the long QT syndrome with induced pluripotent stem cells
Ilanit Itzhaki,Leonid Maizels,Irit Huber,Limor Zwi-Dantsis,Oren Caspi,Aaron Winterstern,Oren Feldman,Amira Gepstein,Gil Arbel,Haim Hammerman,Monther Boulos,Lior Gepstein +11 more
TL;DR: The ability of human iPSC technology to model the abnormal functional phenotype of an inherited cardiac disorder and to identify potential new therapeutic agents represents a promising paradigm to study disease mechanisms, optimize patient care, and aid in the development of new therapies.
Journal ArticleDOI
Electromechanical integration of cardiomyocytes derived from human embryonic stem cells.
Izhak Kehat,Leonid Khimovich,Oren Caspi,Amira Gepstein,Rona Shofti,Gil Arbel,Irit Huber,Jonathan Satin,Joseph Itskovitz-Eldor,Lior Gepstein +9 more
TL;DR: The potential of hES-cell cardiomyocytes to act as a rate-responsive biological pacemaker and for future myocardial regeneration strategies are demonstrated.
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Transplantation of Human Embryonic Stem Cell-Derived Cardiomyocytes Improves Myocardial Performance in Infarcted Rat Hearts
Oren Caspi,Irit Huber,Izhak Kehat,Manhal Habib,Gil Arbel,Amira Gepstein,Lior Yankelson,Doron Aronson,Rafael Beyar,Lior Gepstein +9 more
TL;DR: Transplantation of hESC-CMs after extensive myocardial infarction in rats results in the formation of stable cardiomyocyte grafts, attenuation of the remodeling process, and functional benefit.
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Tissue Engineering of Vascularized Cardiac Muscle From Human Embryonic Stem Cells
Oren Caspi,Ayelet Lesman,Yaara Basevitch,Amira Gepstein,Gil Arbel,Irit Huber Manhal Habib,Lior Gepstein,Shulamit Levenberg +7 more
TL;DR: This is the first report of the construction of 3D vascularized human cardiac tissue that may have unique applications for studies of cardiac development, function, and tissue replacement therapy.
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Cardiomyocyte differentiation of human induced pluripotent stem cells.
TL;DR: In this article, the authors characterized the cardiomyocyte differentiation potential of human induced pluripotent stem (hiPS) cells and studied the molecular, structural, and functional properties of the generated hiPS-derived Cardiomyocytes.