O
Orlando F. Bueno
Researcher at Boston Children's Hospital
Publications - 28
Citations - 5931
Orlando F. Bueno is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Signal transduction & Calcineurin. The author has an hindex of 25, co-authored 28 publications receiving 5632 citations. Previous affiliations of Orlando F. Bueno include Cincinnati Children's Hospital Medical Center & University of Cincinnati.
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Journal ArticleDOI
The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice.
Orlando F. Bueno,Leon J. De Windt,Kevin M. Tymitz,Sandra A. Witt,Thomas R. Kimball,Raisa Klevitsky,Timothy E. Hewett,Steven P. Jones,David J. Lefer,Chang Fu Peng,Richard N. Kitsis,Jeffery D. Molkentin +11 more
TL;DR: The results of the present study indicate that the MEK1–ERK1/2 signaling pathway stimulates a physiologic hypertrophy response associated with augmented cardiac function and partial resistance to apoptotsis.
Journal ArticleDOI
Calcineurin/NFAT Coupling Participates in Pathological, but not Physiological, Cardiac Hypertrophy
Benjamin J. Wilkins,Yan-Shan Dai,Orlando F. Bueno,Stephanie A. Parsons,Jian Xu,David M. Plank,Fred Jones,Thomas R. Kimball,Jeffery D. Molkentin +8 more
TL;DR: The hypothesis that separable signaling pathways regulate pathological versus physiological hypertrophic growth of the myocardium is supported, with calcineurin-NFAT potentially serving a regulatory role that is more specialized for maladaptive hypertrophy and heart failure.
Journal ArticleDOI
Involvement of Extracellular Signal-Regulated Kinases 1/2 in Cardiac Hypertrophy and Cell Death
TL;DR: This review will weigh an increasing body of literature implicating the intermediate signaling pathway consisting of MEK1 and extracellular signal-regulated kinases (ERK1/2) as important regulators of cardiac hypertrophy and myocyte survival.
Journal ArticleDOI
Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling
Julian C. Braz,Orlando F. Bueno,Qiangrong Liang,Benjamin J. Wilkins,Yan-Shan Dai,Stephanie A. Parsons,Joseph Braunwart,Berry J. Glascock,Raisa Klevitsky,Thomas F. Kimball,Timothy E. Hewett,Jeffery D. Molkentin,Jeffery D. Molkentin +12 more
TL;DR: Observations indicate that reduced p38 signaling in the heart promotes myocyte growth through a mechanism involving enhanced calcineurin-NFAT signaling.
Journal ArticleDOI
Targeted Disruption of NFATc3, but Not NFATc4, Reveals an Intrinsic Defect in Calcineurin-Mediated Cardiac Hypertrophic Growth
Benjamin J. Wilkins,Leon J. De Windt,Orlando F. Bueno,Julian C. Braz,Betty J. Glascock,Thomas F. Kimball,Jeffery D. Molkentin +6 more
TL;DR: Genetic evidence that calcineurin-regulated responses require NFAT effectors in vivo is provided, suggesting one mechanism whereby alterations in intracellular calcium handling are linked to the expression of hypertrophy-associated genes.