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Chang Fu Peng
Researcher at Albert Einstein College of Medicine
Publications - 8
Citations - 1242
Chang Fu Peng is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Arc (protein) & Apoptosis. The author has an hindex of 8, co-authored 8 publications receiving 1181 citations. Previous affiliations of Chang Fu Peng include Yeshiva University.
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Journal ArticleDOI
The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice.
Orlando F. Bueno,Leon J. De Windt,Kevin M. Tymitz,Sandra A. Witt,Thomas R. Kimball,Raisa Klevitsky,Timothy E. Hewett,Steven P. Jones,David J. Lefer,Chang Fu Peng,Richard N. Kitsis,Jeffery D. Molkentin +11 more
TL;DR: The results of the present study indicate that the MEK1–ERK1/2 signaling pathway stimulates a physiologic hypertrophy response associated with augmented cardiac function and partial resistance to apoptotsis.
Journal ArticleDOI
Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions.
Young-Jae Nam,Kartik Mani,Anthony W. Ashton,Chang Fu Peng,Barath Krishnamurthy,Yukihiro Hayakawa,Peiyee Lee,Stanley J. Korsmeyer,Richard N. Kitsis +8 more
TL;DR: A critical role is established for nonhomotypic death-fold interactions in the regulation of apoptosis by demonstrating that the CARD-containing protein ARC engages in nontraditional death- fold interactions to suppress both extrinsic and intrinsic death pathways.
Journal ArticleDOI
Regulation of p53 tetramerization and nuclear export by ARC
Roger Foo,Roger Foo,Young-Jae Nam,Marc Jason Ostreicher,Mark D. Metzl,Russell S. Whelan,Chang Fu Peng,Anthony W. Ashton,Weimin Fu,Kartik Mani,Suet-Feung Chin,Elena Provenzano,Ian O. Ellis,Nichola Figg,Sarah E Pinder,Martin R. Bennett,Carlos Caldas,Richard N. Kitsis +17 more
TL;DR: It is concluded that nuclear ARC is induced in cancer cells and negatively regulates p53, which is almost always WT in primary human breast cancers with nuclear ARC.
Journal ArticleDOI
Microarray analysis of global changes in gene expression during cardiac myocyte differentiation.
TL;DR: This first report of large-scale changes in gene expression during cardiac myocyte differentiation has delineated relationships among the expression patterns of known genes and identified a number of novel genes that merit further study.
Journal ArticleDOI
The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant.
Young-Jae Nam,Kartik Mani,Lily Wu,Chang Fu Peng,John W. Calvert,Roger Foo,Barath Krishnamurthy,Wenfeng Miao,Anthony W. Ashton,David J. Lefer,Richard N. Kitsis +10 more
TL;DR: This article showed that ARC protein levels decrease in response to death stimuli in a variety of cell contexts as well as in a model of myocardial ischemia-reperfusion in intact mice.