O
Orly Weinreb
Researcher at Technion – Israel Institute of Technology
Publications - 96
Citations - 6709
Orly Weinreb is an academic researcher from Technion – Israel Institute of Technology. The author has contributed to research in topics: Neuroprotection & Rasagiline. The author has an hindex of 40, co-authored 96 publications receiving 6221 citations. Previous affiliations of Orly Weinreb include Family Research Institute.
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Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration.
TL;DR: Brain penetrating property of polyphenols, as well as their antioxidant and iron‐chelating properties may make such compounds an important class of drugs to be developed for treatment of neurodegenerative diseases where oxidative stress has been implicated.
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Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases
TL;DR: Green tea polyphenols are now being considered as therapeutic agents in well controlled epidemiological studies, aimed to alter brain aging processes and to serve as possible neuroprotective agents in progressive neurodegenerative disorders such as Parkinson's and Alzheimer's diseases.
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Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate: implications for neurodegenerative diseases.
TL;DR: Both experimental and epidemiological evidence demonstrate that flavonoid polyphenols, particularly from green tea and blueberries, improve age‐related cognitive decline and are neuroprotective in models of PD, AD and cerebral ischemia/reperfusion injuries.
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Multifunctional activities of green tea catechins in neuroprotection. Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway.
Silvia Mandel,Yael Avramovich-Tirosh,Lydia Reznichenko,Hailin Zheng,Orly Weinreb,Tamar Amit,Moussa B.H. Youdim +6 more
TL;DR: This review will focus on the multifunctional properties of green tea and its major component (–)-epigallocatechin-3-gallate (EGCG) and their ability to induce neuroprotection and neurorescue in vitro and in vivo and their transitional metal chelating property and inhibition of oxidative stress.
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Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders.
TL;DR: Light is shed on the multipharmacological neuroprotective activities of green tea catechins with special emphasis on their brain-permeable, nontoxic, transitional metal (iron and copper)-chelatable/radical scavenger properties.