Ossama B. Kashlan

TL;DR: The structure and function of the key transporters and the complex interplay of regulatory factors that modulate principal cell ion and water transport are addressed.

TL;DR: Data are consistent with Hsc70 and Hsp70 having differential and antagonistic effects with regard to the intracellular trafficking of mENaC in oocytes, which may have an impact on the understanding and potential treatment of diseases of aberrant ion channel trafficking.

TL;DR: Functional data is examined, including ion selectivity, gating, and amiloride block, in light of the resolved ASIC1 structure to examine the role of extracellular and pore regions in channel assembly, processing, and the ability of these channels to sense the external environment.

TL;DR: It is shown that acetylcholine is a competitive antagonist for ELIC, and the structural underpinning of the functional relationship between agonism and competitive antagonism in the Cys-loop receptors is presented, providing a new framework for developing novel therapeutic drugs.

TL;DR: Other factors, including acidic phospholipids and modification of ENaC cytoplasmic cysteine residues by palmitoylation, which enhance channel activity by altering interactions of the channel with the plasma membrane, are addressed.