O
Otmar Pachinger
Researcher at Innsbruck Medical University
Publications - 192
Citations - 6326
Otmar Pachinger is an academic researcher from Innsbruck Medical University. The author has contributed to research in topics: Coronary artery disease & Myocardial infarction. The author has an hindex of 44, co-authored 191 publications receiving 6000 citations. Previous affiliations of Otmar Pachinger include University of Innsbruck.
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Journal ArticleDOI
HMG-CoA Reductase Inhibitors Regulate Inflammatory Transcription Factors in Human Endothelial and Vascular Smooth Muscle Cells
Wolfgang Dichtl,Jozef Dulak,Matthias Frick,Hannes Alber,Severin P. Schwarzacher,Mikko P.S. Ares,Jan Nilsson,Otmar Pachinger,Franz Weidinger +8 more
TL;DR: Findings support the concept that statins have antiinflammatory and antiproliferative effects that are relevant in the treatment of atherosclerotic diseases.
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Endothelial Dysfunction Induced by Hyperhomocyst(e)inemia Role of Asymmetric Dimethylarginine
Markus Stühlinger,Roberta K. Oka,Eric E. Graf,Isabella Schmölzer,Barbara Upson,Om Kapoor,Andrzej Szuba,M. Rene Malinow,Thomas C. Wascher,Otmar Pachinger,John P. Cooke +10 more
TL;DR: It is suggested that experimental hyperhomocyst(e)inemia leads to accumulation of the endogenous NO synthase inhibitor ADMA, accompanied by varying degrees of endothelial dysfunction according to the preexisting state of cardiovascular health.
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Head-to-head comparison of N-terminal pro-brain natriuretic peptide, brain natriuretic peptide and N-terminal pro-atrial natriuretic peptide in diagnosing left ventricular dysfunction.
Angelika Hammerer-Lercher,Elke Neubauer,Silvana Müller,Otmar Pachinger,Bernd Puschendorf,Johannes Mair +5 more
TL;DR: In this paper, the authors measured brain natriuretic peptide (BNP), NT-proBNP, and Pro-atrial natriive peptide(NT-proANP) for the detection of heart failure.
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Heme oxygenase activity modulates vascular endothelial growth factor synthesis in vascular smooth muscle cells.
Jozef Dulak,Alicja Jozkowicz,Roberta Foresti,Aneta Kasza,Matthias Frick,Ihor Huk,Colin J. Green,Otmar Pachinger,Franz Weidinger,Roberto Motterlini +9 more
TL;DR: The data indicate that HO-1 activity influences the generation of VEGF in VSMC in both normoxic and hypoxic conditions, and indicates that CO and iron, respectively the inducer and the inhibitor of V EGF synthesis, are concomitantly produced during the degradation of heme.
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Genetic augmentation of nitric oxide synthase increases the vascular generation of VEGF.
Alicja Jozkowicz,John P. Cooke,Ibeth Guevara,Ihor Huk,Philip Funovics,Otmar Pachinger,Franz Weidinger,Jozef Dulak,Jozef Dulak +8 more
TL;DR: These studies reveal that NO derived from NO-donors or generated by NOS within the cells, upregulates the synthesis of VEGF in vascular smooth muscle cells, an alternative approach in therapeutic angiogenesis.