O
Otmar Trentz
Researcher at University of Zurich
Publications - 199
Citations - 10856
Otmar Trentz is an academic researcher from University of Zurich. The author has contributed to research in topics: Traumatic brain injury & Sepsis. The author has an hindex of 55, co-authored 199 publications receiving 10366 citations. Previous affiliations of Otmar Trentz include École Polytechnique Fédérale de Lausanne & University of Konstanz.
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Journal ArticleDOI
Pathophysiology of polytrauma.
Marius Keel,Otmar Trentz +1 more
TL;DR: Whereas most clinical trials with anti-inflammatory, anti-coagulant, or antioxidant strategies failed, the implementation of pre- and in-hospital trauma protocols and the principle of damage control procedures have reduced post-traumatic complications, the development of immunomonitoring will help in the selection of patients at risk of post- traumatic complications and the choice of the most appropriate treatment protocols for severely injured patients.
Journal ArticleDOI
Downregulation of proinflammatory cytokine release in whole blood from septic patients.
Wolfgang Ertel,Jean-Pierre Kremer,John S. Kenney,Ursula Steckholzer,Doraid Jarrar,Otmar Trentz,Friedrich Wilhelm Schildberg +6 more
TL;DR: Data indicate a downregulatory mechanism of cytokine release in whole blood from patients with severe sepsis that occurs on different levels.
Journal ArticleDOI
IL-10 levels in cerebrospinal fluid and serum of patients with severe traumatic brain injury: relationship to IL-6, TNF-α, TGF-β1 and blood–brain barrier function
Esther Csuka,Maria Cristina Morganti-Kossmann,Philipp M. Lenzlinger,Helen Joller,Otmar Trentz,Thomas Kossmann +5 more
TL;DR: IL-10 is predominantly induced intrathecally after severe TBI where it may downregulate inflammatory events following traumatic brain damage and be independent from severe BBB dysfunction.
Journal ArticleDOI
Interleukin-10 Counterregulates Proinflammatory Cytokine-Induced Inhibition of Neutrophil Apoptosis During Severe Sepsis
Marius Keel,Udo Ungethüm,Udo Ungethüm,Ursula Steckholzer,Ursula Steckholzer,Eva Niederer,Eva Niederer,Thomas Hartung,Thomas Hartung,Otmar Trentz,Otmar Trentz,Wolfgang Ertel,Wolfgang Ertel +12 more
TL;DR: Proinflammatory cytokines and IL-10 are identified as strong regulators of spontaneous neutrophil apoptosis during sepsis, which seems to be associated with alterations of signal transduction pathways.
Journal ArticleDOI
Incidence and clinical pattern of the abdominal compartment syndrome after "damage-control" laparotomy in 311 patients with severe abdominal and/or pelvic trauma
TL;DR: Risk factors for the occurrence of ACS are severe abdominal and/or pelvic trauma, which require laparotomy and packing for the control of hemorrhage and a critical rise in intracranial pressure in patients with combined abdominal/pelvic and head trauma.