P
P A Bernabei
Researcher at University of Florence
Publications - 5
Citations - 473
P A Bernabei is an academic researcher from University of Florence. The author has contributed to research in topics: Haematopoiesis & Progenitor cell. The author has an hindex of 5, co-authored 5 publications receiving 463 citations.
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Journal ArticleDOI
HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors.
Serena Pillozzi,Maria Felice Brizzi,Manuela Balzi,Olivia Crociani,Alessia Cherubini,Leonardo Guasti,Benedetta Bartolozzi,Andrea Becchetti,Enzo Wanke,P A Bernabei,Massimo Olivotto,Luigi Pegoraro,Annarosa Arcangeli +12 more
TL;DR: It is reported here that herg is switched off in normal peripheral blood mononuclear cells (PBMNC) as well as in circulating CD34+ cells, however, it is rapidly turned on in the latter upon induction of the mitotic cycle.
Journal ArticleDOI
Incubation of murine bone marrow cells in hypoxia ensures the maintenance of marrow‐repopulating ability together with the expansion of committed progenitors
Zoran Ivanovic,Benedetta Bartolozzi,P A Bernabei,Maria Grazia Cipolleschi,Elisabetta Rovida,Pavle Milenković,Vincent Praloran,P. Dello Sbarba +7 more
TL;DR: Severe hypoxia is able to ensure a full maintenance of progenitors sustaining MRA, together with a significant expansion of in vitro‐detectable clonogenic progenitor, including those endowed with replating ability, which could contribute to the improvement of current techniques for the in vitro treatment of human haematopoietic cell populations before transplantation.
Journal ArticleDOI
HERG K+ channels activation during beta(1) integrin-mediated adhesion to fibronectin induces an up-regulation of alpha(v)beta(3) integrin in the preosteoclastic leukemia cell line FLG 29.1.
Giovanna Hofmann,P A Bernabei,Olivia Crociani,Alessia Cherubini,Leonardo Guasti,Serena Pillozzi,Elena Lastraioli,Simone Polvani,Benedetta Bartolozzi,Vera Solazzo,Laura Gragnani,Paola Defilippi,Barbara Rosati,Enzo Wanke,Massimo Olivotto,Annarosa Arcangeli +15 more
TL;DR: It is demonstrated that the modulation of the electrical potential of the plasma membrane (VREST) is an early integrin-mediated signal, which is related to neurite emission in neuroblastoma cells and appears to be a determinant signal for the up-regulation of αvβ3 integrin, as well as for the increased expression of calcitonin receptor.
Journal Article
Severe hypoxia enhances the formation of erythroid bursts from human cord blood cells and the maintenance of BFU-E in vitro
Maria Grazia Cipolleschi,Gianluca D'Ippolito,P A Bernabei,Roberto Caporale,R Nannini,M Mariani,M Fabbiani,P. Rossi-Ferrini,Massimo Olivotto,P. Dello Sbarba +9 more
TL;DR: Results indicate that hypoxia inversely regulates two subsequent phases of erythropoiesis, i.e., it enhances the maintenance of BFU-E and the early development of ERYthroid clones but inhibits the terminal expansion and maturation of these clones.
Journal ArticleDOI
A simple, one-step clonal assay allows the sequential detection of committed (CFU-GM-like) progenitors and several subsets of primitive (HPP-CFC) murine progenitors.
Zoran Ivanovic,Benedetta Bartolozzi,P A Bernabei,Maria Grazia Cipolleschi,Pavle Milenković,Vincent Praloran,Persio Dello Sbarba +6 more
TL;DR: This simple, rapid, and versatile method allows the detection of a broad range of hematopoietic progenitors in murine BM, from committed progenitor to largely quiescent, primitive stem cells, as well as the evaluation of the progenites' self‐renewal and proliferative potential.