L
Luigi Pegoraro
Researcher at University of Turin
Publications - 106
Citations - 4044
Luigi Pegoraro is an academic researcher from University of Turin. The author has contributed to research in topics: Interleukin 3 & Leukemia. The author has an hindex of 34, co-authored 106 publications receiving 3977 citations.
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Journal ArticleDOI
Selective growth response to IL‐3 of a human leukaemic cell line with megakaryoblastic features
Gian Carlo Avanzi,Patrizia Lista,Bruna Giovinazzo,Roberto Miniero,Giuseppe Saglio,G. Benetton,Renato Coda,Giorgio Cattoretti,Luigi Pegoraro +8 more
TL;DR: Of the haemopoietic growth factors tested for their ability to restore the proliferative activity of this quiescent population, only rH IL‐3 proved effective and increased the cloning efficiency in methylcellulose more than any other CSFs.
Journal ArticleDOI
A 14;18 and an 8;14 chromosome translocation in a cell line derived from an acute B-cell leukemia
Luigi Pegoraro,Antonio Palumbo,Jan Erikson,Michele Falda,Bruna Giovanazzo,Beverly S. Emanuel,Giovanni Giac. Rovera,Peter C. Nowell,Carlo M. Croce +8 more
TL;DR: A model of some aspects of B-cell oncogenesis is proposed according to which B- cell neoplasms carrying translocations involving the heavy chain loci on both human chromosomes 14 are the result of a multiple step process.
Journal ArticleDOI
HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors.
Serena Pillozzi,Maria Felice Brizzi,Manuela Balzi,Olivia Crociani,Alessia Cherubini,Leonardo Guasti,Benedetta Bartolozzi,Andrea Becchetti,Enzo Wanke,P A Bernabei,Massimo Olivotto,Luigi Pegoraro,Annarosa Arcangeli +12 more
TL;DR: It is reported here that herg is switched off in normal peripheral blood mononuclear cells (PBMNC) as well as in circulating CD34+ cells, however, it is rapidly turned on in the latter upon induction of the mitotic cycle.
Journal ArticleDOI
VEGFR-1 (FLT-1), β1 integrin, and hERG K+ channel for a macromolecular signaling complex in acute myeloid leukemia: role in cell migration and clinical outcome
Serena Pillozzi,Maria Felice Brizzi,P. A. Bernabei,Benedetta Bartolozzi,Roberto Caporale,Venere Basile,Vieri Boddi,Luigi Pegoraro,Andrea Becchetti,Annarosa Arcangeli +9 more
TL;DR: It is concluded that in AML, hERG1 channels mediate the FLT-1-dependent cell migration and invasion, and hence confer a greater malignancy.
Journal Article
Establishment of a Ph1-positive human cell line (BV173).
TL;DR: A new cell line (BV173) derived from a patient with Philadelphia chromosome (Ph1)-positive acute leukemia was compared with the Ph1-positive K562 and NALM-1 lines, which display the phenotypic characteristics of erythroid and pre-B cells, respectively.