L
Leonardo Guasti
Researcher at Queen Mary University of London
Publications - 64
Citations - 3373
Leonardo Guasti is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Adrenal cortex & hERG. The author has an hindex of 30, co-authored 63 publications receiving 2864 citations. Previous affiliations of Leonardo Guasti include University of Florence & UCL Institute of Child Health.
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Journal ArticleDOI
MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans
Claire Hughes,Leonardo Guasti,Eirini Meimaridou,Chen-Hua Chuang,John C. Schimenti,Peter J. King,Colm Costigan,Adrian J. L. Clark,Louise A. Metherell +8 more
TL;DR: What is believed to be the first human mutation in minichromosome maintenance-deficient 4 (MCM4) is identified and shown that it is associated with adrenal insufficiency, short stature, and NK cell deficiency.
Journal ArticleDOI
herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells.
Elena Lastraioli,Leonardo Guasti,Olivia Crociani,Simone Polvani,Giovanna Hofmann,Harry J. Witchel,Lapo Bencini,Massimo Calistri,Luca Messerini,Marco Scatizzi,Renato Moretti,Enzo Wanke,Massimo Olivotto,Gabriele Mugnai,Annarosa Arcangeli +14 more
TL;DR: It is reported in this article that K+ ion channels belonging to the HERG family are important determinants for the acquisition of an invasive phenotype in colorectal cancers.
Journal ArticleDOI
MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family
Li F. Chan,Tom R. Webb,Teng-Teng Chung,Eirini Meimaridou,Sadani N. Cooray,Leonardo Guasti,J. Paul Chapple,Michaela Egertová,Maurice R. Elphick,Michael E. Cheetham,Louise A. Metherell,Adrian J. L. Clark +11 more
TL;DR: MRAP and MRAP2 are identified as unique bidirectional regulators of the MCR family, and can reduce MC1R,MC3R, MC4R, and MC5R responsiveness to [Nle4,D-Phe7]alpha-melanocyte-stimulating hormone (NDP-MSH).
Journal ArticleDOI
Cell Cycle-dependent Expression of HERG1 and HERG1B Isoforms in Tumor Cells
Olivia Crociani,Leonardo Guasti,Manuela Balzi,Andrea Becchetti,Enzo Wanke,Massimo Olivotto,Randy S. Wymore,Annarosa Arcangeli +7 more
TL;DR: It is demonstrated that in tumor cells the value of V m is clamped to rather depolarized values by K+ channels belonging to the HERG family, suggesting that modulated expression of different K+ channel is the molecular basis of a novel mechanism regulating neoplastic cell proliferation.
Journal ArticleDOI
HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors.
Serena Pillozzi,Maria Felice Brizzi,Manuela Balzi,Olivia Crociani,Alessia Cherubini,Leonardo Guasti,Benedetta Bartolozzi,Andrea Becchetti,Enzo Wanke,P A Bernabei,Massimo Olivotto,Luigi Pegoraro,Annarosa Arcangeli +12 more
TL;DR: It is reported here that herg is switched off in normal peripheral blood mononuclear cells (PBMNC) as well as in circulating CD34+ cells, however, it is rapidly turned on in the latter upon induction of the mitotic cycle.