P
P. Jeffrey Conn
Researcher at Vanderbilt University
Publications - 542
Citations - 26166
P. Jeffrey Conn is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Metabotropic glutamate receptor & Allosteric regulation. The author has an hindex of 79, co-authored 524 publications receiving 23776 citations. Previous affiliations of P. Jeffrey Conn include University of Texas Southwestern Medical Center & Johnson & Johnson.
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Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease
TL;DR: The widespread expression of mGluRs makes these receptors particularly attractive drug targets, and recent studies continue to validate the therapeutic utility of m GluR ligands in neurological and psychiatric disorders such as Alzheimer's disease, Parkinson's Disease, anxiety, depression, and schizophrenia.
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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
TL;DR: There have been tremendous advances in the discovery of novel ligands for GPCRs that act at allosteric sites to regulate receptor function that provide high selectivity, novel modes of efficacy and may lead to novel therapeutic agents for the treatment of multiple psychiatric and neurological human disorders.
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Metabotropic glutamate receptors in brain function and pathology
TL;DR: The molecular aspects and pharmacology of mGluRs, and recent studies elucidating their role in brain function and pathology are reviewed.
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Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator
Huixian Wu,Chong Wang,Karen J. Gregory,Karen J. Gregory,Gye Won Han,Hyekyung P. Cho,Yan Xia,Colleen M. Niswender,Vsevolod Katritch,Jens Meiler,Vadim Cherezov,P. Jeffrey Conn,Raymond C. Stevens +12 more
TL;DR: A combination of crystallography, structure-activity relationships, mutagenesis, and full-length dimer modeling provides insights about the allosteric modulation and activation mechanism of class C GPCRs.
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Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.
TL;DR: It is reported that activation of group I metabotropic glutamate receptors (mGluRs) induces a direct excitation of STN neurons that is characterized by depolarization, increased firing frequency, and increased burst-firing activity, and the results suggest that mGluR5 may play an important role in the net excitatory drive to the STN from glutamatergic afferents.