Yoland Smith

TL;DR: The findings summarized in this commentary confirm and elaborate the models of the direct and indirect pathways of information flow through the basal ganglia and provide a morphological framework for future studies.

TL;DR: In patients with Parkinson's disease the loss of dopamine is predominantly in the posterior putamen, a region of the basal ganglia associated with the control of habitual behaviour, and patients may be forced into a progressive reliance on the goal-directed mode of action control that is mediated by comparatively preserved processing in the rostromedial striatum.

TL;DR: This review emphasizes the high degree of anatomical and functional specificity of basal ganglia-thalamostriatal projections and discusses various aspects of the synaptic connectivity and neurochemical features that differentiate this glutamate system from the corticostRIatal network.

TL;DR: The goal was to use microarray and complementary technologies in adolescent rats to understand the anticonvulsant effect of the ketogenic diet, which typically is used in pediatric epilepsies, but is effective also in adolescents and adults.

TL;DR: Hallmark features of HD, including nuclear inclusions and neuropil aggregates, were observed in the brains of the HD transgenic monkeys, and the data suggest that it will be feasible to generate valuable non-human primate models of HD and possibly other human genetic diseases.