P. Nardi

TL;DR: Estrogen treatment improves calcium malabsorption induced by surgical or natural menopause, but the mechanisms involved are still under debate, with both increased production of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] and improved peripheral responsiveness to the steroid having been proposed.

TL;DR: It is demonstrated that 1 year treatment with estrogens improves both intestinal calcium absorption and BMC in postmenopausal osteoporotic women, and vitamin D metabolites do not seem to contribute substantially to the mediation of estrogen action on bone.

TL;DR: It is suggested that L-lysine can both enhance intestinal Ca absorption and improve the renal conservation of the absorbed Ca, which may contribute to a positive Ca balance, thus suggesting a potential usefulness of L- Elysine supplements for both preventive and therapeutic interventions in osteoporosis.

TL;DR: The data are consistent with the fact that the skeletal effects of prednisone therapy are mediated, at least in part, by increased parathyroid hormone activity, and that deflazacort is less potent in this regard.

TL;DR: This study examined the characteristics of 147 PDB cases from Italy and showed a reduced clinical severity of PDB with respect to other populations and provided further support of the importance of environmental factors (rural area of residence and animal contact) in the pathogenesis of P DB.