P
P. Raghuraman
Researcher at VIT University
Publications - 11
Citations - 63
P. Raghuraman is an academic researcher from VIT University. The author has contributed to research in topics: Cyclic nucleotide-binding domain & Sequence motif. The author has an hindex of 5, co-authored 10 publications receiving 46 citations.
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Differentially expressed gene (DEG) based protein-protein interaction (PPI) network identifies a spectrum of gene interactome, transcriptome and correlated miRNA in nondisjunction Down syndrome
TL;DR: A consolidative network approach to comprehend the intricacy of the associated genes of Down syndrome and the enriched pathway could help understand at a molecular level and eventually used as therapeutic targets for Down syndrome.
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R516Q mutation in Melanoma differentiation-associated protein 5 (MDA5) and its pathogenic role towards rare Singleton-Merten syndrome; a signature associated molecular dynamics study.
P. Raghuraman,C. Sudandiradoss +1 more
TL;DR: It is emphasised that the dislocation of functional hot spots Pro229, Arg414, Val498, Met510, Ala513, Gly515 and Arg516 in MDA5 protein which is important for interior structural packing and fold arrangements will have potential implications in immune therapeutical advancement for rare singleton-merten syndrome.
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Systematic prioritization of functional hotspot in RIG-1 domains using pattern based conventional molecular dynamic simulation.
TL;DR: Structural variations owing to hotspot residues in mutants again confirm the significance of these residues in structural characterization of RIG‐1 domains and help the researchers to better comprehend towards regulatory regions and target‐binding sites for therapeutic design within the pattern recognition receptor proteins.
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A molecular simulation analysis of vitamin D targets interleukin 13 (IL13) as an alternative to mometasone in asthma.
TL;DR: The substitution of vitamin D might provide a promising gateway to reduce the side effects caused by mometasone and also reduce the cost for treatment of asthma patients.
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Casting the critical regions in nucleotide binding oligomerization domain 2 protein: a signature mediated structural dynamics approach.
TL;DR: This protocol will help the researchers to achieve for more prospective studies to attest druggable site utility in discovering novel drug candidates and to identify hotspots that serve as critical points to maintain the stable architecture of the protein.