P. Scott Carney

Abstract: State-of-the-art methods in high-resolution three-dimensional optical microscopy require that the focus be scanned through the entire region of interest. However, an analysis of the physics of the light–sample interaction reveals that the Fourier-space coverage is independent of depth. Here we show that, by solving the inverse scattering problem for interference microscopy, computed reconstruction yields volumes with a resolution in all planes that is equivalent to the resolution achieved only at the focal plane for conventional high-resolution microscopy. In short, the entire illuminated volume has spatially invariant resolution, thus eliminating the compromise between resolution and depth of field. We describe and demonstrate a novel computational image-formation technique called interferometric synthetic aperture microscopy (ISAM). ISAM has the potential to broadly impact real-time three-dimensional microscopy and analysis in the fields of cell and tumour biology, as well as in clinical diagnosis where in vivo imaging is preferable to biopsy.

TL;DR: A method to correct aberrations in a tomogram rather than the beam of a broadband optical interferometry system based on Fourier optics principles, which enables object reconstruction (within the single scattering limit) with ideal focal-plane resolution at all depths.

TL;DR: Interferometric synthetic aperture microscopy provides high-resolution three-dimensional optical images of highly-scattering samples with large depth-of-field without scanning the focal plane to provide volumes of microscopic data from biological specimens.

TL;DR: In this article, gate-induced tunneling through a Schottky barrier located at the interface between a metallic source electrode and the Si channel was explored to forestall short-channel effects.

TL;DR: This work quantitatively measures local dielectric constants and infrared absorption of samples with 2 orders of magnitude improved spatial resolution compared to far-field measurements and obtains local infrared absorption spectra with unprecedented accuracy in peak position and shape, which is the key to quantitative chemometrics on the nanometer scale.