Tyler S. Ralston

Abstract: State-of-the-art methods in high-resolution three-dimensional optical microscopy require that the focus be scanned through the entire region of interest. However, an analysis of the physics of the light–sample interaction reveals that the Fourier-space coverage is independent of depth. Here we show that, by solving the inverse scattering problem for interference microscopy, computed reconstruction yields volumes with a resolution in all planes that is equivalent to the resolution achieved only at the focal plane for conventional high-resolution microscopy. In short, the entire illuminated volume has spatially invariant resolution, thus eliminating the compromise between resolution and depth of field. We describe and demonstrate a novel computational image-formation technique called interferometric synthetic aperture microscopy (ISAM). ISAM has the potential to broadly impact real-time three-dimensional microscopy and analysis in the fields of cell and tumour biology, as well as in clinical diagnosis where in vivo imaging is preferable to biopsy.

TL;DR: Interferometric synthetic aperture microscopy provides high-resolution three-dimensional optical images of highly-scattering samples with large depth-of-field without scanning the focal plane to provide volumes of microscopic data from biological specimens.

TL;DR: A real-time acquisition and processing architecture has been developed for an ultrawideband (UWB) S-band (2–4 GHz) multiple-input multiple-output (MIMO) phased array radar system that facilitates greater than 10 Hz imaging rates, providing a video-like radar image of what is behind a concrete wall.

TL;DR: Inverse scattering theory for optical coherence tomography (OCT) is developed in this paper, and the results are used to produce algorithms to resolve three-dimensional object structure, taking into account the finite beam width, diffraction, and defocusing effects.

TL;DR: In this article, the authors describe ultrasound imaging devices, which operate in a transmissive ultrasound imaging modality, and which may be used to detect properties of interest of a subject such as index of refraction, density and/or speed of sound.