P.V. Srinivas

TL;DR: The methanolic extract of rhizome of Himalayan rhubarb Rheum emodi displayed mild yeast as well as mammalian intestinal alpha-glucosidase inhibitory activity, but the isolation of several potent molecules in excellent yields showed that these compounds may have value in the treatment and prevention of hyperglycemia associated diabetes mellitus.

TL;DR: It was observed that most of the derivatives displayed significant activity as compared to their parent compound (chrysin), and all the derivatives were screened for antibacterial activity against a panel of susceptible and resistant Gram-positive and Gram-negative organisms.

TL;DR: In this investigation for the anticancer constituents from the hexane extract of this plant, a new sesquiterpene was isolated along with the known compounds costunolide, beta-cyclocostunolides, dihydro costunOLide and dehydro costuslactone, and all the compounds were tested for their in vitro cytotoxic activity.

TL;DR: The bioassay-guided chemical examination of the rhizomes of R. emodi resulted in the isolation of two new oxanthrone esters and a new anthraquinone ether revandchinone-4, establishing new structures based on spectroscopic and degradative evidence.

TL;DR: A bioguided extraction and fractionation of the petroleum ether extract of the berries of P. nigrum afforded compounds that were active against Bacillus subtilis, Bacillus sphaericus, and Staphylococcus aureus amongst Gram + ve bacteria, and Klebsiella aerogenes and Chromobacterium violaceum among Gram -ve bacterial strains.