P
Pablo Javier Patiño
Researcher at University of Antioquia
Publications - 33
Citations - 514
Pablo Javier Patiño is an academic researcher from University of Antioquia. The author has contributed to research in topics: Gene & Chronic granulomatous disease. The author has an hindex of 12, co-authored 33 publications receiving 426 citations.
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Journal ArticleDOI
Recombination events between the p47-phox gene and its highly homologous pseudogenes are the main cause of autosomal recessive chronic granulomatous disease.
Joachim Roesler,John T. Curnutte,Julie Rae,David E. Barrett,Pablo Javier Patiño,Stephen J. Chanock,Agnes Goerlach +6 more
TL;DR: A sequence analysis of 28 unrelated, racially diverse A47 degrees CGD patients and 37 healthy individuals concluded that recombination events between the p47-phox gene and its highly homologous pseudogenes result in the incorporation of triangle upGT into the p 47- phox gene, thereby leading to the high frequency of GT deletion in A47 DegreesCGD patients.
Journal ArticleDOI
Antibody Responses in COVID-19: A Review.
Mateo Chvatal-Medina,Yorjagis Mendez-Cortina,Pablo Javier Patiño,Paula A. Velilla,María Teresa Rugeles +4 more
TL;DR: In this article, the seroconversion of IgM and IgG occurs at around 12 days post onset of symptoms and most patients have neutralizing titers on days 14-20, with great titer variability.
Journal ArticleDOI
p40phox: the last NADPH oxidase subunit.
TL;DR: An improved understanding of p40phox should provide new insights about NADPH oxidase, the physiology of phagocytic cells and the innate immune system.
Journal ArticleDOI
Dexamethasone inhibits apoptosis of human neutrophils induced by reactive oxygen species.
TL;DR: The G/GO system is a useful model to simulate the oxidative stress of neutrophils, and the effect of DXM on neutrophil apoptosis depends, at least in part, on blocking the proapoptotic effect of ROS.
Journal ArticleDOI
Molecular analysis of chronic granulomatous disease caused by defects in gp91‐phox
Pablo Javier Patiño,Juan E. Pérez,Juan Álvaro López,Antonio Condino-Neto,Anete Sevciovic Grumach,J H Botero,John T. Curnutte,D García de Olarte +7 more
TL;DR: The molecular characterization of seven unrelated kindreds native from Colombia and Brazil with CGD caused by gp91‐phox deficiency is reported, which indicates a de novo mutation in this kindred.